C-linked Glycosyl Azido Acids in Novel Solid-Phase C-Glycopeptide Synthesis

U Tedbark, M Meldal, Luigi PANZA, K. Bock

Risultato della ricerca: Contributo su rivistaArticolo in rivista

Abstract

A C-linked gylosyl decapeptide was synthesized on solid-phase by a combination of the Fmoc-method and a novel method of using azido acids with reductive deprotection. The unprotected C-glycosyl azido acid building block was incorparated by a TBTU coupling, subsequently reduced using DTT in DMF and followed by further Fmoc-amino acid-OPfp ester couplings. Mouse hemoglobin(67-76) carrying the C-linked glycoside in position 72 was prepared as a metabolically stable T-cell glycopeptide antigen.

Lingua originaleInglese
pagine (da-a)1815-1818
Numero di pagine4
RivistaTetrahedron Letters
Volume39
Stato di pubblicazionePubblicato - 1998

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