Abstract
A C-linked gylosyl decapeptide was synthesized on solid-phase by a combination of the Fmoc-method and a novel method of using azido acids with reductive deprotection. The unprotected C-glycosyl azido acid building block was incorparated by a TBTU coupling, subsequently reduced using DTT in DMF and followed by further Fmoc-amino acid-OPfp ester couplings. Mouse hemoglobin(67-76) carrying the C-linked glycoside in position 72 was prepared as a metabolically stable T-cell glycopeptide antigen.
Lingua originale | Inglese |
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pagine (da-a) | 1815-1818 |
Numero di pagine | 4 |
Rivista | Tetrahedron Letters |
Volume | 39 |
Stato di pubblicazione | Pubblicato - 1998 |