Breastfeeding and Endometrial Cancer Risk: An Analysis from the Epidemiology of Endometrial Cancer Consortium

S. J. Jordan; R. Na; S. E. Johnatty; L. A. Wise; H. O. Adami; L. A. Brinton; C. Chen; L. S. Cook; Maso L. Dal; Vivo I. De; J. L. Freudenheim; C. M. Friedenreich; Vecchia C. La; S. E. McCann; K. B. Moysich; L. Lu; S. H. Olson; J. R. Palmer; S. Petruzella; M. C. Pike; T. R. Rebbeck; F. Ricceri; H. A. Risch; Carlotta SACERDOTE; V. W. Setiawan; T. R. Sponholtz; X. O. Shu; A. B. Spurdle; E. Weiderpass; N. Wentzensen; H. P. Yang; H. Yu; P. M. Webb

doi:10.1097/AOG.0000000000002057

Breastfeeding and Endometrial Cancer Risk: An Analysis from the Epidemiology of Endometrial Cancer Consortium

S. J. Jordan, R. Na, S. E. Johnatty, L. A. Wise, H. O. Adami, L. A. Brinton, C. Chen, L. S. Cook, Maso L. Dal, Vivo I. De, J. L. Freudenheim, C. M. Friedenreich, Vecchia C. La, S. E. McCann, K. B. Moysich, L. Lu, S. H. Olson, J. R. Palmer, S. Petruzella, M. C. PikeT. R. Rebbeck, F. Ricceri, H. A. Risch, Carlotta SACERDOTE, V. W. Setiawan, T. R. Sponholtz, X. O. Shu, A. B. Spurdle, E. Weiderpass, N. Wentzensen, H. P. Yang, H. Yu, P. M. Webb

Dipartimento di Scienze della Salute

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

OBJECTIVE: To investigate the association between breastfeeding and endometrial cancer risk using pooled data from 17 studies participating in the Epidemiology of Endometrial Cancer Consortium. METHODS: We conducted a meta-analysis with individuallevel data from three cohort and 14 case-control studies. Study-specific odds ratios (ORs) and 95% confidence intervals (CIs) were estimated for the association between breastfeeding and risk of endometrial cancer using multivariable logistic regression and pooled using random-effects meta-analysis. We investigated between-study heterogeneity with I2 and Q statistics and metaregression. RESULTS: After excluding nulliparous women, the analyses included 8,981 women with endometrial cancer and 17,241 women in a control group. Ever breastfeeding was associated with an 11% reduction in risk of endometrial cancer (pooled OR 0.89, 95% CI 0.81-0.98). Longer average duration of breastfeeding per child was associated with lower risk of endometrial cancer, although there appeared to be some leveling of this effect beyond 6-9 months. The association with ever breastfeeding was not explained by greater parity and did not vary notably by body mass index or histologic subtype (grouped as endometrioid and mucinous compared with serous and clear cell). CONCLUSION: Our findings suggest that reducing endometrial cancer risk can be added to the list of maternal benefits associated with breastfeeding. Ongoing promotion, support, and facilitation of this safe and beneficial behavior might therefore contribute to the prevention of this increasingly common cancer.

Lingua originale	Inglese
pagine (da-a)	1059-1067
Numero di pagine	9
Rivista	Obstetrics and Gynecology
Volume	129
Numero di pubblicazione	6
DOI	https://doi.org/10.1097/AOG.0000000000002057
Stato di pubblicazione	Pubblicato - 2017

Keywords

Endometrial Neoplasms
Female
Global Health
Humans
Risk Factors
Risk Reduction Behavior
Women's Health
Breast Feeding

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https://hdl.handle.net/11579/177006

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Jordan, S. J., Na, R., Johnatty, S. E., Wise, L. A., Adami, H. O., Brinton, L. A., Chen, C., Cook, L. S., Dal, M. L., De, V. I., Freudenheim, J. L., Friedenreich, C. M., La, V. C., McCann, S. E., Moysich, K. B., Lu, L., Olson, S. H., Palmer, J. R., Petruzella, S., ... Webb, P. M. (2017). Breastfeeding and Endometrial Cancer Risk: An Analysis from the Epidemiology of Endometrial Cancer Consortium. Obstetrics and Gynecology, 129(6), 1059-1067. https://doi.org/10.1097/AOG.0000000000002057

@article{c2895b41e35f443f9b2700b6f5f8d429,

title = "Breastfeeding and Endometrial Cancer Risk: An Analysis from the Epidemiology of Endometrial Cancer Consortium",

abstract = "OBJECTIVE: To investigate the association between breastfeeding and endometrial cancer risk using pooled data from 17 studies participating in the Epidemiology of Endometrial Cancer Consortium. METHODS: We conducted a meta-analysis with individuallevel data from three cohort and 14 case-control studies. Study-specific odds ratios (ORs) and 95% confidence intervals (CIs) were estimated for the association between breastfeeding and risk of endometrial cancer using multivariable logistic regression and pooled using random-effects meta-analysis. We investigated between-study heterogeneity with I2 and Q statistics and metaregression. RESULTS: After excluding nulliparous women, the analyses included 8,981 women with endometrial cancer and 17,241 women in a control group. Ever breastfeeding was associated with an 11% reduction in risk of endometrial cancer (pooled OR 0.89, 95% CI 0.81-0.98). Longer average duration of breastfeeding per child was associated with lower risk of endometrial cancer, although there appeared to be some leveling of this effect beyond 6-9 months. The association with ever breastfeeding was not explained by greater parity and did not vary notably by body mass index or histologic subtype (grouped as endometrioid and mucinous compared with serous and clear cell). CONCLUSION: Our findings suggest that reducing endometrial cancer risk can be added to the list of maternal benefits associated with breastfeeding. Ongoing promotion, support, and facilitation of this safe and beneficial behavior might therefore contribute to the prevention of this increasingly common cancer.",

keywords = "Endometrial Neoplasms, Female, Global Health, Humans, Risk Factors, Risk Reduction Behavior, Women's Health, Breast Feeding, Endometrial Neoplasms, Female, Global Health, Humans, Risk Factors, Risk Reduction Behavior, Women's Health, Breast Feeding",

author = "Jordan, {S. J.} and R. Na and Johnatty, {S. E.} and Wise, {L. A.} and Adami, {H. O.} and Brinton, {L. A.} and C. Chen and Cook, {L. S.} and Dal, {Maso L.} and De, {Vivo I.} and Freudenheim, {J. L.} and Friedenreich, {C. M.} and La, {Vecchia C.} and McCann, {S. E.} and Moysich, {K. B.} and L. Lu and Olson, {S. H.} and Palmer, {J. R.} and S. Petruzella and Pike, {M. C.} and Rebbeck, {T. R.} and F. Ricceri and Risch, {H. A.} and Carlotta SACERDOTE and Setiawan, {V. W.} and Sponholtz, {T. R.} and Shu, {X. O.} and Spurdle, {A. B.} and E. Weiderpass and N. Wentzensen and Yang, {H. P.} and H. Yu and Webb, {P. M.}",

year = "2017",

doi = "10.1097/AOG.0000000000002057",

language = "English",

volume = "129",

pages = "1059--1067",

journal = "Obstetrics and Gynecology",

issn = "0029-7844",

publisher = "Lippincott Williams and Wilkins",

number = "6",

}

Jordan, SJ, Na, R, Johnatty, SE, Wise, LA, Adami, HO, Brinton, LA, Chen, C, Cook, LS, Dal, ML, De, VI, Freudenheim, JL, Friedenreich, CM, La, VC, McCann, SE, Moysich, KB, Lu, L, Olson, SH, Palmer, JR, Petruzella, S, Pike, MC, Rebbeck, TR, Ricceri, F, Risch, HA, SACERDOTE, C, Setiawan, VW, Sponholtz, TR, Shu, XO, Spurdle, AB, Weiderpass, E, Wentzensen, N, Yang, HP, Yu, H & Webb, PM 2017, 'Breastfeeding and Endometrial Cancer Risk: An Analysis from the Epidemiology of Endometrial Cancer Consortium', Obstetrics and Gynecology, vol. 129, n. 6, pagg. 1059-1067. https://doi.org/10.1097/AOG.0000000000002057

TY - JOUR

T1 - Breastfeeding and Endometrial Cancer Risk: An Analysis from the Epidemiology of Endometrial Cancer Consortium

AU - Jordan, S. J.

AU - Na, R.

AU - Johnatty, S. E.

AU - Wise, L. A.

AU - Adami, H. O.

AU - Brinton, L. A.

AU - Chen, C.

AU - Cook, L. S.

AU - Dal, Maso L.

AU - De, Vivo I.

AU - Freudenheim, J. L.

AU - Friedenreich, C. M.

AU - La, Vecchia C.

AU - McCann, S. E.

AU - Moysich, K. B.

AU - Lu, L.

AU - Olson, S. H.

AU - Palmer, J. R.

AU - Petruzella, S.

AU - Pike, M. C.

AU - Rebbeck, T. R.

AU - Ricceri, F.

AU - Risch, H. A.

AU - SACERDOTE, Carlotta

AU - Setiawan, V. W.

AU - Sponholtz, T. R.

AU - Shu, X. O.

AU - Spurdle, A. B.

AU - Weiderpass, E.

AU - Wentzensen, N.

AU - Yang, H. P.

AU - Yu, H.

AU - Webb, P. M.

PY - 2017

Y1 - 2017

N2 - OBJECTIVE: To investigate the association between breastfeeding and endometrial cancer risk using pooled data from 17 studies participating in the Epidemiology of Endometrial Cancer Consortium. METHODS: We conducted a meta-analysis with individuallevel data from three cohort and 14 case-control studies. Study-specific odds ratios (ORs) and 95% confidence intervals (CIs) were estimated for the association between breastfeeding and risk of endometrial cancer using multivariable logistic regression and pooled using random-effects meta-analysis. We investigated between-study heterogeneity with I2 and Q statistics and metaregression. RESULTS: After excluding nulliparous women, the analyses included 8,981 women with endometrial cancer and 17,241 women in a control group. Ever breastfeeding was associated with an 11% reduction in risk of endometrial cancer (pooled OR 0.89, 95% CI 0.81-0.98). Longer average duration of breastfeeding per child was associated with lower risk of endometrial cancer, although there appeared to be some leveling of this effect beyond 6-9 months. The association with ever breastfeeding was not explained by greater parity and did not vary notably by body mass index or histologic subtype (grouped as endometrioid and mucinous compared with serous and clear cell). CONCLUSION: Our findings suggest that reducing endometrial cancer risk can be added to the list of maternal benefits associated with breastfeeding. Ongoing promotion, support, and facilitation of this safe and beneficial behavior might therefore contribute to the prevention of this increasingly common cancer.

AB - OBJECTIVE: To investigate the association between breastfeeding and endometrial cancer risk using pooled data from 17 studies participating in the Epidemiology of Endometrial Cancer Consortium. METHODS: We conducted a meta-analysis with individuallevel data from three cohort and 14 case-control studies. Study-specific odds ratios (ORs) and 95% confidence intervals (CIs) were estimated for the association between breastfeeding and risk of endometrial cancer using multivariable logistic regression and pooled using random-effects meta-analysis. We investigated between-study heterogeneity with I2 and Q statistics and metaregression. RESULTS: After excluding nulliparous women, the analyses included 8,981 women with endometrial cancer and 17,241 women in a control group. Ever breastfeeding was associated with an 11% reduction in risk of endometrial cancer (pooled OR 0.89, 95% CI 0.81-0.98). Longer average duration of breastfeeding per child was associated with lower risk of endometrial cancer, although there appeared to be some leveling of this effect beyond 6-9 months. The association with ever breastfeeding was not explained by greater parity and did not vary notably by body mass index or histologic subtype (grouped as endometrioid and mucinous compared with serous and clear cell). CONCLUSION: Our findings suggest that reducing endometrial cancer risk can be added to the list of maternal benefits associated with breastfeeding. Ongoing promotion, support, and facilitation of this safe and beneficial behavior might therefore contribute to the prevention of this increasingly common cancer.

KW - Endometrial Neoplasms

KW - Female

KW - Global Health

KW - Humans

KW - Risk Factors

KW - Risk Reduction Behavior

KW - Women's Health

KW - Breast Feeding

KW - Endometrial Neoplasms

KW - Female

KW - Global Health

KW - Humans

KW - Risk Factors

KW - Risk Reduction Behavior

KW - Women's Health

KW - Breast Feeding

UR - https://iris.uniupo.it/handle/11579/177006

U2 - 10.1097/AOG.0000000000002057

DO - 10.1097/AOG.0000000000002057

M3 - Article

SN - 0029-7844

VL - 129

SP - 1059

EP - 1067

JO - Obstetrics and Gynecology

JF - Obstetrics and Gynecology

IS - 6

ER -

Breastfeeding and Endometrial Cancer Risk: An Analysis from the Epidemiology of Endometrial Cancer Consortium

Abstract

Keywords

OSS delle Nazioni Unite

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