Bone marrow necrosis complicating post-transplant lymphoproliferative disorder: Resolution with rituximab

Davide Rossi; Antonio Ramponi; Silvia Franceschetti; Piero Stratta; Gianluca Gaidano

doi:10.1016/j.leukres.2007.10.007

Bone marrow necrosis complicating post-transplant lymphoproliferative disorder: Resolution with rituximab

Davide Rossi, Antonio Ramponi, Silvia Franceschetti, Piero Stratta, Gianluca Gaidano

Dipartimento di Medicina Traslazionale

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

Bone marrow necrosis is a rare cause of bone marrow failure. Malignancy is the most frequent cause of bone marrow necrosis. Among malignancies, non-Hodgkin lymphoma (NHL) accounts for 10% of cases of bone marrow necrosis. Virtually all reported cases of NHL-associated bone marrow necrosis have developed in immunocompetent hosts. We report on a case of bone marrow necrosis complicating post-transplant lymphoproliferative disorder (PTLD) and resolving after rituximab monotherapy. This case report provides the first evidence of (i) bone marrow necrosis as a complication of PTLD; (ii) rapid resolution of NHL-associated bone marrow necrosis after rituximab treatment.

Lingua originale	Inglese
pagine (da-a)	829-834
Numero di pagine	6
Rivista	Leukemia Research
Volume	32
Numero di pubblicazione	5
DOI	https://doi.org/10.1016/j.leukres.2007.10.007
Stato di pubblicazione	Pubblicato - mag 2008

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10.1016/j.leukres.2007.10.007

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title = "Bone marrow necrosis complicating post-transplant lymphoproliferative disorder: Resolution with rituximab",

abstract = "Bone marrow necrosis is a rare cause of bone marrow failure. Malignancy is the most frequent cause of bone marrow necrosis. Among malignancies, non-Hodgkin lymphoma (NHL) accounts for 10% of cases of bone marrow necrosis. Virtually all reported cases of NHL-associated bone marrow necrosis have developed in immunocompetent hosts. We report on a case of bone marrow necrosis complicating post-transplant lymphoproliferative disorder (PTLD) and resolving after rituximab monotherapy. This case report provides the first evidence of (i) bone marrow necrosis as a complication of PTLD; (ii) rapid resolution of NHL-associated bone marrow necrosis after rituximab treatment.",

keywords = "Bone marrow necrosis, Non-Hodgkin lymphoma, Post-transplant lymphoproliferative disorder, Renal transplantation, Rituximab",

author = "Davide Rossi and Antonio Ramponi and Silvia Franceschetti and Piero Stratta and Gianluca Gaidano",

note = "Funding Information: This study has been supported by Ricerca Sanitaria Finalizzata and Ricerca Scientifica Applicata, Regione Piemonte, Torino, Italy; PRIN 2006, Rome, Italy; and Novara-AIL Onlus, Novara, Italy. ",

year = "2008",

month = may,

doi = "10.1016/j.leukres.2007.10.007",

language = "English",

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T1 - Bone marrow necrosis complicating post-transplant lymphoproliferative disorder

T2 - Resolution with rituximab

AU - Rossi, Davide

AU - Ramponi, Antonio

AU - Franceschetti, Silvia

AU - Stratta, Piero

AU - Gaidano, Gianluca

N1 - Funding Information: This study has been supported by Ricerca Sanitaria Finalizzata and Ricerca Scientifica Applicata, Regione Piemonte, Torino, Italy; PRIN 2006, Rome, Italy; and Novara-AIL Onlus, Novara, Italy.

PY - 2008/5

Y1 - 2008/5

N2 - Bone marrow necrosis is a rare cause of bone marrow failure. Malignancy is the most frequent cause of bone marrow necrosis. Among malignancies, non-Hodgkin lymphoma (NHL) accounts for 10% of cases of bone marrow necrosis. Virtually all reported cases of NHL-associated bone marrow necrosis have developed in immunocompetent hosts. We report on a case of bone marrow necrosis complicating post-transplant lymphoproliferative disorder (PTLD) and resolving after rituximab monotherapy. This case report provides the first evidence of (i) bone marrow necrosis as a complication of PTLD; (ii) rapid resolution of NHL-associated bone marrow necrosis after rituximab treatment.

AB - Bone marrow necrosis is a rare cause of bone marrow failure. Malignancy is the most frequent cause of bone marrow necrosis. Among malignancies, non-Hodgkin lymphoma (NHL) accounts for 10% of cases of bone marrow necrosis. Virtually all reported cases of NHL-associated bone marrow necrosis have developed in immunocompetent hosts. We report on a case of bone marrow necrosis complicating post-transplant lymphoproliferative disorder (PTLD) and resolving after rituximab monotherapy. This case report provides the first evidence of (i) bone marrow necrosis as a complication of PTLD; (ii) rapid resolution of NHL-associated bone marrow necrosis after rituximab treatment.

KW - Bone marrow necrosis

KW - Non-Hodgkin lymphoma

KW - Post-transplant lymphoproliferative disorder

KW - Renal transplantation

KW - Rituximab

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U2 - 10.1016/j.leukres.2007.10.007

DO - 10.1016/j.leukres.2007.10.007

M3 - Article

SN - 0145-2126

VL - 32

SP - 829

EP - 834

JO - Leukemia Research

JF - Leukemia Research

IS - 5

ER -

Bone marrow necrosis complicating post-transplant lymphoproliferative disorder: Resolution with rituximab

Abstract

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