Biologically active nanoparticles of a carbonate-substituted hydroxyapatite, process for their preparation and composition incorporating the same

GUALANDI P. (Inventore), ROVERI N. (Inventore), Lia RIMONDINI (Inventore), PALAZZO B. (Inventore), IAFISCO M. (Inventore), GAZZANIGA G. (Inventore)

Risultato della ricerca: Brevetto

Abstract

he invention relates to biologically active nanoparticles of a carbonate-substituted non-stoichiometric hydroxyapatite, having: a) a crystallinity degree CD lower than 40%, the crystallinity degree being defined as CD=(1-X/Y)center dot 100 wherein: Y=height of the diffraction maximum at 2 theta=33 degrees, X=height of the diffraction background at 2 theta=33 degrees of the nanoparticles X-ray diffraction pattern; b) a length L ranging from 20 to 200 nm and a width W ranging from 5 to 30 nm; and c) an aspect ratio AR comprised between 2 and 40, the aspect ratio being defined as AR=L/W. The biologically active nanoparticles of the invention find a preferred use in oral or dental hygiene applications and may be formulated as compositions for oral or dental hygiene such as, for example, solutions, suspensions, oils, gels or other solid products. Other aspects of the invention include a process for preparing a suspension for oral or dental hygiene including the aforementioned biologically active nanoparticles, a process for manufacturing a toothpaste comprising the nanoparticles, as well as a method of locally remineralizing the teeth comprising contacting the teeth with the nanoparticles.
Lingua originaleInglese
Numero di brevettoUS 08367043
Data della priorità5/02/13
Stato di pubblicazionePubblicato - 1 gen 2013

Fingerprint

Entra nei temi di ricerca di 'Biologically active nanoparticles of a carbonate-substituted hydroxyapatite, process for their preparation and composition incorporating the same'. Insieme formano una fingerprint unica.

Cita questo