TY - PAT
T1 - Biologically active nanoparticles of a carbonate-substituted hydroxyapatite, process for their preparation and composition incorporating the same
AU - P., GUALANDI
AU - N., ROVERI
AU - RIMONDINI, Lia
AU - B., PALAZZO
AU - M., IAFISCO
AU - G., GAZZANIGA
PY - 2013/1/1
Y1 - 2013/1/1
N2 - he invention relates to biologically active nanoparticles of a carbonate-substituted non-stoichiometric hydroxyapatite, having: a) a crystallinity degree CD lower than 40%, the crystallinity degree being defined as CD=(1-X/Y)center dot 100 wherein: Y=height of the diffraction maximum at 2 theta=33 degrees, X=height of the diffraction background at 2 theta=33 degrees of the nanoparticles X-ray diffraction pattern; b) a length L ranging from 20 to 200 nm and a width W ranging from 5 to 30 nm; and c) an aspect ratio AR comprised between 2 and 40, the aspect ratio being defined as AR=L/W. The biologically active nanoparticles of the invention find a preferred use in oral or dental hygiene applications and may be formulated as compositions for oral or dental hygiene such as, for example, solutions, suspensions, oils, gels or other solid products. Other aspects of the invention include a process for preparing a suspension for oral or dental hygiene including the aforementioned biologically active nanoparticles, a process for manufacturing a toothpaste comprising the nanoparticles, as well as a method of locally remineralizing the teeth comprising contacting the teeth with the nanoparticles.
AB - he invention relates to biologically active nanoparticles of a carbonate-substituted non-stoichiometric hydroxyapatite, having: a) a crystallinity degree CD lower than 40%, the crystallinity degree being defined as CD=(1-X/Y)center dot 100 wherein: Y=height of the diffraction maximum at 2 theta=33 degrees, X=height of the diffraction background at 2 theta=33 degrees of the nanoparticles X-ray diffraction pattern; b) a length L ranging from 20 to 200 nm and a width W ranging from 5 to 30 nm; and c) an aspect ratio AR comprised between 2 and 40, the aspect ratio being defined as AR=L/W. The biologically active nanoparticles of the invention find a preferred use in oral or dental hygiene applications and may be formulated as compositions for oral or dental hygiene such as, for example, solutions, suspensions, oils, gels or other solid products. Other aspects of the invention include a process for preparing a suspension for oral or dental hygiene including the aforementioned biologically active nanoparticles, a process for manufacturing a toothpaste comprising the nanoparticles, as well as a method of locally remineralizing the teeth comprising contacting the teeth with the nanoparticles.
UR - https://iris.uniupo.it/handle/11579/19532
M3 - Patent
M1 - US 08367043
ER -