Biological performances of collagen-based scaffolds for vascular tissue engineering

F. Boccafoschi, J. Habermehl, S. Vesentini, D. Mantovani

Risultato della ricerca: Contributo su rivistaArticolo in rivistapeer review

Abstract

Collagen is widely used for biomedical applications and it could represent a valid alternative scaffold material for vascular tissue engineering. In this work, reconstituted collagen films were prepared from neutralized acid-soluble solutions for subsequent haemocompatibility and cell viability performance assays. First, haemoglobin-free, thrombelastography and platelet adhesion tests were performed in order to investigate the blood contact performance. Secondly, specimens were seeded with endothelial cells and smooth muscle cells, and cell viability tests were carried out by MTT and SEM. Results show that neutralized acid-soluble type I collagen films do not enhance blood coagulation, do not alter normal viscoelastic properties of blood and slightly activate platelet adhesion and aggregation. Cell culture shows that the samples are adequate substrates to support the adhesion and proliferation of endothelial and smooth muscle cells.

Lingua originaleInglese
pagine (da-a)7410-7417
Numero di pagine8
RivistaBiomaterials
Volume26
Numero di pubblicazione35
DOI
Stato di pubblicazionePubblicato - dic 2005

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