Biodegradable micro and nanoparticles for controlled drug release

C. Mattu, S. Sartori, E. Ranzato, M. Boffito, R. Li, G. Ciardelli

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Abstract

In this paper, we propose the encapsulation of the anticancer drug Paclitaxel into biodegrdable polymeric carriers to improve the release properties of the active principle. Commercial polyesthers, such as Poly-ε-Caprolactone (PCL) or Poly Lactic Acid (PLA) and a series of proprietary polyester-urethanes (PU) were selected to prepare micro or nanoparticles for controlled drug release. The Solvent Displacement Method or the Oil in Water single Emulsion Solvent Extraction Evaporation Method were optimized to prepare colloidal carriers with tunable release profiles and encapsulation properties.

Lingua originaleInglese
Titolo della pubblicazione ospiteTechnical Proceedings of the 2011 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2011
Pagine314-317
Numero di pagine4
Stato di pubblicazionePubblicato - 2011
EventoNanotechnology 2011: Electronics, Devices, Fabrication, MEMS, Fluidics and Computational - 2011 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2011 - Boston, MA, United States
Durata: 13 giu 201116 giu 2011

Serie di pubblicazioni

NomeTechnical Proceedings of the 2011 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2011
Volume3

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???event.eventtypes.event.conference???Nanotechnology 2011: Electronics, Devices, Fabrication, MEMS, Fluidics and Computational - 2011 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2011
Paese/TerritorioUnited States
CittàBoston, MA
Periodo13/06/1116/06/11

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