Bioactive triterpenoids from the caffeine-rich plants guayusa and maté

G. Chianese, S. D. Golin-Pacheco, O. Taglialatela-Scafati, J. A. Collado, E. Munoz, G. Appendino, F. Pollastro

Risultato della ricerca: Contributo su rivistaArticolo in rivistapeer review

Abstract

Unlike all other caffeinated plants, guayusa (Ilex guayusa Loes.) and maté (Ilex paraguariensis A. St. Hill) contain high amounts of pentacyclic triterpenoid acids and alcohols. A phytochemical investigation on these plants revealed a similar triterpenoid profile and a content of ursolic acid (0.7–1%) and amyrin esters (up to 0.5%), quite unusual for dietary plants. The major constituent of the amyrin complex from both plants is α-amyrin palmitate (2a), accompanied by lower amounts of its corresponding palmitoleate (2b) and by the corresponding constitutional isomers from the β-series (3a and 3b, respectively). Ursolic acid (1) was identified as the responsible for the activity of maté and guayusa extracts in the activation of TGR5, a nuclear receptor of relevance for the prevention and management of diabetes and metabolic syndrome because of its involvement in the regulation of energy expenditure and insulin sensitivity.

Lingua originaleInglese
pagine (da-a)504-510
Numero di pagine7
RivistaFood Research International
Volume115
DOI
Stato di pubblicazionePubblicato - gen 2019

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