Behavioral effects of phosphatidylserine in aged rats

F. Drago, P. L. Canonico, U. Scapagnini

Risultato della ricerca: Contributo su rivistaArticolo in rivistapeer review

Abstract

The behavioral effects of 5 days of administration of phosphatidylserine (PS) was studied in aged rats. The intraperitoneal (5, 10, and 20 mg/kg) or intracerebroventricular (5, 10, and 20 μg/2 μl) injection of PS liposomes caused a facilitated acquisition of active avoidance behavior as studied in shuttle-box and pole jumping test situations. The retention of active and passive avoidance responses was also improved. No substantial difference between PS-treated and control animals was apparent either in the responsiveness to electrical footshock or in the motor activity tested in an open field. Grooming behavior appeared to be enhanced in rats treated with the highest dose of the substance. Since PS affects both central catecholaminergic and cholinergic transmission, which is known to be impaired in old animals, the possibility that the behavioral effects of PS involve brain dopamine and/or acetylcholine systems is discussed.

Lingua originaleInglese
pagine (da-a)209-213
Numero di pagine5
RivistaNeurobiology of Aging
Volume2
Numero di pubblicazione3
DOI
Stato di pubblicazionePubblicato - 1981
Pubblicato esternamente

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