TY - JOUR
T1 - B‐cell chronic lymphocytic leukaemia stage 0. An immunophenotypic study of 66 cases and comparison with B small cell lymphomas
AU - Stramignoni, Aldo
AU - Valente, Guido
AU - Geuna, Massimo
AU - Stramignoni, Daniela
AU - Novero, Domenico
AU - Ragona, Riccardo
AU - Resegotti, Luigi
AU - Palestro, Giorgio
PY - 1994/3
Y1 - 1994/3
N2 - Abstract: The cells of 66 B‐CLL stage 0 patients were analyzed using a large panel of monoclonal antibodies in order to better define the immunophenotype of B‐CLL. The data were compared with the immunophenotypes of lymph node cells from 51 patients with diffuse B small cell lymphoma or leukaemia with lymph node enlargement. The most frequent immunophenotype of B‐CLL stage 0 was SIgM(D)+ EmR+ CD5+ CD9+ CD21+ CD23+ CD35– CD38–. Among the lymphomas, EmR‐positive and EmR‐negative cases were identified. The vast majority of the EmR‐positive cases usually showed the leukaemic pattern, immunophenotype and lymph node histology of B‐CLL. The EmR‐negative cases usually had immunophenotypes quite different from those of B‐CLL and the histology of indented cell lymphoma (centrocytic or intermediate) or features of lymphoplasmacytoid/cytic lymphoma. More than 20% of EmR‐positive cells proved to be the most important marker to distinguish B‐CLL from other lymphocytic lymphomas. Indeed this was a sign of better prognosis. Lymphoplasmacytoid/cytic lymphomas were EmR‐positive with the immunophenotype of B‐CLL or EmR‐negative with a definitely different immunological profile. This suggests two morphologically similar but biologically different subgroups of these diseases.
AB - Abstract: The cells of 66 B‐CLL stage 0 patients were analyzed using a large panel of monoclonal antibodies in order to better define the immunophenotype of B‐CLL. The data were compared with the immunophenotypes of lymph node cells from 51 patients with diffuse B small cell lymphoma or leukaemia with lymph node enlargement. The most frequent immunophenotype of B‐CLL stage 0 was SIgM(D)+ EmR+ CD5+ CD9+ CD21+ CD23+ CD35– CD38–. Among the lymphomas, EmR‐positive and EmR‐negative cases were identified. The vast majority of the EmR‐positive cases usually showed the leukaemic pattern, immunophenotype and lymph node histology of B‐CLL. The EmR‐negative cases usually had immunophenotypes quite different from those of B‐CLL and the histology of indented cell lymphoma (centrocytic or intermediate) or features of lymphoplasmacytoid/cytic lymphoma. More than 20% of EmR‐positive cells proved to be the most important marker to distinguish B‐CLL from other lymphocytic lymphomas. Indeed this was a sign of better prognosis. Lymphoplasmacytoid/cytic lymphomas were EmR‐positive with the immunophenotype of B‐CLL or EmR‐negative with a definitely different immunological profile. This suggests two morphologically similar but biologically different subgroups of these diseases.
KW - chronic lymphocytic leukaemia
KW - non‐Hodgkin's lymphoma‐immunophenotype
UR - http://www.scopus.com/inward/record.url?scp=0028235426&partnerID=8YFLogxK
U2 - 10.1111/j.1600-0609.1994.tb01305.x
DO - 10.1111/j.1600-0609.1994.tb01305.x
M3 - Article
SN - 0902-4441
VL - 52
SP - 145
EP - 151
JO - European Journal of Haematology
JF - European Journal of Haematology
IS - 3
ER -