TY - JOUR
T1 - Basic Fibroblast Growth Factor Opens Calcium‐Permeable Channels in Quail Mesencephalic Neural Crest Neurons
AU - Distasi, Carla
AU - Munaron, Luca
AU - Laezza, Fernanda
AU - Lovisolo, Davide
PY - 1995/3
Y1 - 1995/3
N2 - In order to investigate the action of basic fibroblast growth factor (bFGF) in the nervous system, we have studied the ionic signals elicited by this peptide in cultured quail mesencephalic neural crest neurons using patch‐clamp and cytofluorimetric techniques. In this preparation stimulation with bFGF induced, with a delay of some tens of seconds, an inward cationic current. Single‐channel experiments provided evidence for the activation of a calcium‐permeable channel. In single‐cell cytofluorimetric measurements, a sustained rise in [Ca2+Ii was observed, which was dependent on the presence of external calcium. These events may play a role in the developmental effects of bFGF.
AB - In order to investigate the action of basic fibroblast growth factor (bFGF) in the nervous system, we have studied the ionic signals elicited by this peptide in cultured quail mesencephalic neural crest neurons using patch‐clamp and cytofluorimetric techniques. In this preparation stimulation with bFGF induced, with a delay of some tens of seconds, an inward cationic current. Single‐channel experiments provided evidence for the activation of a calcium‐permeable channel. In single‐cell cytofluorimetric measurements, a sustained rise in [Ca2+Ii was observed, which was dependent on the presence of external calcium. These events may play a role in the developmental effects of bFGF.
KW - calcium influx
KW - cytosolic calcium increase
KW - neuronal development
UR - http://www.scopus.com/inward/record.url?scp=0028900430&partnerID=8YFLogxK
U2 - 10.1111/j.1460-9568.1995.tb00348.x
DO - 10.1111/j.1460-9568.1995.tb00348.x
M3 - Article
SN - 0953-816X
VL - 7
SP - 516
EP - 520
JO - European Journal of Neuroscience
JF - European Journal of Neuroscience
IS - 3
ER -