TY - JOUR
T1 - Basal and stress-induced release of noradrenaline in hypothalamus of spontaneously hypertensive rats at different ages
AU - Terrazzino, S.
AU - Perego, C.
AU - Vetrugno, G.
AU - De Simoni, G.
N1 - Funding Information:
S.T. is a fellow of the "Banca Popolare di Milano". This work was partiallys upportedb y the Italian Consortium for Technologiesa nd Drugs for Cerebral Aging of the Italian Ministry of Universitiesa nd Scientific and TechnologicaRl esearch.T he work was also partially supportedb y the National ResearchC ouncilPsy-chopharmacologPyro ject.
PY - 1994/12/30
Y1 - 1994/12/30
N2 - Basal and stress-induced noradrenaline (NA) release was studied by intracerebral microdialysis in the hypothalamic paraventricular nucleus of spontaneously hypertensive rats (SHR) at different ages (9 weeks, 6, 18 and 24 months). NA was measured in 20-min dialysate samples by high performance liquid chromatography with electrochemical detection. Microdialysis sampling was done at baseline, during a 20-min immobilization stress and for the next 100 min. Basal NA levels decreased with age, showing a highly significant correlation. Immobilization stress raised NA similarly in the four age groups (respectively 281%, 235%, 243%, 251% of baseline at 9 weeks, 6, 18, 24 months), indicating that the response to stress is maintained at all these ages and is not affected by the development of hypertension or by aging.
AB - Basal and stress-induced noradrenaline (NA) release was studied by intracerebral microdialysis in the hypothalamic paraventricular nucleus of spontaneously hypertensive rats (SHR) at different ages (9 weeks, 6, 18 and 24 months). NA was measured in 20-min dialysate samples by high performance liquid chromatography with electrochemical detection. Microdialysis sampling was done at baseline, during a 20-min immobilization stress and for the next 100 min. Basal NA levels decreased with age, showing a highly significant correlation. Immobilization stress raised NA similarly in the four age groups (respectively 281%, 235%, 243%, 251% of baseline at 9 weeks, 6, 18, 24 months), indicating that the response to stress is maintained at all these ages and is not affected by the development of hypertension or by aging.
KW - Aging
KW - Hypothalamic paraventricular nucleus
KW - Immobilization stress
KW - Intracerebral microdialysis
KW - Noradrenaline
KW - Spontaneously hypertensive rat
UR - http://www.scopus.com/inward/record.url?scp=0028555346&partnerID=8YFLogxK
U2 - 10.1016/0006-8993(94)90533-9
DO - 10.1016/0006-8993(94)90533-9
M3 - Article
SN - 0006-8993
VL - 668
SP - 256
EP - 260
JO - Brain Research
JF - Brain Research
IS - 1-2
ER -