Abstract
The intermolecular [3 + 2] with 2(2-nitrophenyl)acrylate dienophiles followed by reductive heterocyclization affords the spiro(indole-pyrrolidine) ring system. Hence, this enable us to accomplish a concise and highly enantioselective synthesis of (-)-horsfiline 1, based on chiral auxiliary-directed π-face discrimination in the 1,3-dipolar cycloaddition of (1S,2R)- 2-phenyl-1-cyclohexyl ester 4f with N-methylazomethine ylide.
Lingua originale | Inglese |
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pagine (da-a) | 8447-8453 |
Numero di pagine | 7 |
Rivista | Journal of Organic Chemistry |
Volume | 66 |
Numero di pubblicazione | 25 |
DOI | |
Stato di pubblicazione | Pubblicato - 14 dic 2001 |