Association of Vitamin D pathway SNPs and clinical response to interferon in a cohort of HBeAg-negative patients

Jessica Cusato; Lucio Boglione; Amedeo De Nicolò; Rosaria Imbornone; Chiara Simona Cardellino; Valeria Ghisetti; Chiara Carcieri; Giuseppe Cariti; Giovanni Di Perri; Antonio D'Avolio

doi:10.2217/pgs-2016-0041

Association of Vitamin D pathway SNPs and clinical response to interferon in a cohort of HBeAg-negative patients

Jessica Cusato, Lucio Boglione, Amedeo De Nicolò, Rosaria Imbornone, Chiara Simona Cardellino, Valeria Ghisetti, Chiara Carcieri, Giuseppe Cariti, Giovanni Di Perri, Antonio D'Avolio

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

Aim: Vitamin D modulates biological processes; an influence of vitamin D levels and genetic variants was identified concerning hepatitis B virus infection. We evaluated the role of some SNPs of vitamin D pathway genes in some clinical features of hepatitis B affected patients treated with pegylated interferon. Methods: We investigated SNPs in IL-28B, CYP27B1, CYP27A1, CYP24A1, VDBP and VDR genes, through real-time PCR. Results: VDRApaI SNP was associated to viral load and HBsAg presence at different timings. In logistic regression analyses, VDRApaI AA genotype predicted baseline viral load >6 Log IU/ml (marker of nonresponse), and both virological and biochemical responses. Conclusion: Pharmacogenetic data could help physicians in the prediction of patients with higher probability to achieve a good response.

Lingua originale	Inglese
pagine (da-a)	651-661
Numero di pagine	11
Rivista	Pharmacogenomics
Volume	18
Numero di pubblicazione	7
DOI	https://doi.org/10.2217/pgs-2016-0041
Stato di pubblicazione	Pubblicato - mag 2017
Pubblicato esternamente	Sì

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title = "Association of Vitamin D pathway SNPs and clinical response to interferon in a cohort of HBeAg-negative patients",

abstract = "Aim: Vitamin D modulates biological processes; an influence of vitamin D levels and genetic variants was identified concerning hepatitis B virus infection. We evaluated the role of some SNPs of vitamin D pathway genes in some clinical features of hepatitis B affected patients treated with pegylated interferon. Methods: We investigated SNPs in IL-28B, CYP27B1, CYP27A1, CYP24A1, VDBP and VDR genes, through real-time PCR. Results: VDRApaI SNP was associated to viral load and HBsAg presence at different timings. In logistic regression analyses, VDRApaI AA genotype predicted baseline viral load >6 Log IU/ml (marker of nonresponse), and both virological and biochemical responses. Conclusion: Pharmacogenetic data could help physicians in the prediction of patients with higher probability to achieve a good response.",

keywords = "VDR genes, calcitriol, pharmacogenetics",

author = "Jessica Cusato and Lucio Boglione and {De Nicol{\`o}}, Amedeo and Rosaria Imbornone and Cardellino, {Chiara Simona} and Valeria Ghisetti and Chiara Carcieri and Giuseppe Cariti and {Di Perri}, Giovanni and Antonio D'Avolio",

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year = "2017",

month = may,

doi = "10.2217/pgs-2016-0041",

language = "English",

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T1 - Association of Vitamin D pathway SNPs and clinical response to interferon in a cohort of HBeAg-negative patients

AU - Cusato, Jessica

AU - Boglione, Lucio

AU - De Nicolò, Amedeo

AU - Imbornone, Rosaria

AU - Cardellino, Chiara Simona

AU - Ghisetti, Valeria

AU - Carcieri, Chiara

AU - Cariti, Giuseppe

AU - Di Perri, Giovanni

AU - D'Avolio, Antonio

PY - 2017/5

Y1 - 2017/5

N2 - Aim: Vitamin D modulates biological processes; an influence of vitamin D levels and genetic variants was identified concerning hepatitis B virus infection. We evaluated the role of some SNPs of vitamin D pathway genes in some clinical features of hepatitis B affected patients treated with pegylated interferon. Methods: We investigated SNPs in IL-28B, CYP27B1, CYP27A1, CYP24A1, VDBP and VDR genes, through real-time PCR. Results: VDRApaI SNP was associated to viral load and HBsAg presence at different timings. In logistic regression analyses, VDRApaI AA genotype predicted baseline viral load >6 Log IU/ml (marker of nonresponse), and both virological and biochemical responses. Conclusion: Pharmacogenetic data could help physicians in the prediction of patients with higher probability to achieve a good response.

AB - Aim: Vitamin D modulates biological processes; an influence of vitamin D levels and genetic variants was identified concerning hepatitis B virus infection. We evaluated the role of some SNPs of vitamin D pathway genes in some clinical features of hepatitis B affected patients treated with pegylated interferon. Methods: We investigated SNPs in IL-28B, CYP27B1, CYP27A1, CYP24A1, VDBP and VDR genes, through real-time PCR. Results: VDRApaI SNP was associated to viral load and HBsAg presence at different timings. In logistic regression analyses, VDRApaI AA genotype predicted baseline viral load >6 Log IU/ml (marker of nonresponse), and both virological and biochemical responses. Conclusion: Pharmacogenetic data could help physicians in the prediction of patients with higher probability to achieve a good response.

KW - VDR genes

KW - calcitriol

KW - pharmacogenetics

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DO - 10.2217/pgs-2016-0041

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JO - Pharmacogenomics

JF - Pharmacogenomics

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ER -

Association of Vitamin D pathway SNPs and clinical response to interferon in a cohort of HBeAg-negative patients

Abstract

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