TY - JOUR
T1 - Assessment of the potential of SiPM-based systems for bioluminescence detection
AU - Lomazzi, S.
AU - Caccia, M.
AU - Distasi, C.
AU - Dionisi, M.
AU - Lim, D.
AU - Martemiyanov, A.
AU - Nardo, L.
AU - Ruffinatti, F. A.
AU - Santoro, R.
N1 - Publisher Copyright:
© 2020
PY - 2020/11/1
Y1 - 2020/11/1
N2 - Bioluminescence detection requires single-photon sensitivity, extremely low detection limits and wide dynamic range. Such performances were traditionally assured by photomultiplier-tubes based systems. However, development of novel applications and industrialization call for the introduction of more robust, compact and scalable devices. Silicon photomultipliers were recently put forward as the alternative to phototubes for a new generation of flexible and user friendly instruments. In this article, the figures of merit of a silicon-photomultiplier based system relying on a compact, low cost system are investigated. Possible implementations are proposed and a proof-of-principle bioluminescence measurement is performed.
AB - Bioluminescence detection requires single-photon sensitivity, extremely low detection limits and wide dynamic range. Such performances were traditionally assured by photomultiplier-tubes based systems. However, development of novel applications and industrialization call for the introduction of more robust, compact and scalable devices. Silicon photomultipliers were recently put forward as the alternative to phototubes for a new generation of flexible and user friendly instruments. In this article, the figures of merit of a silicon-photomultiplier based system relying on a compact, low cost system are investigated. Possible implementations are proposed and a proof-of-principle bioluminescence measurement is performed.
KW - Bioluminescence
KW - Charge integration
KW - Dynamic range
KW - Limit of detection
KW - SiPM
KW - Single photon counting
UR - http://www.scopus.com/inward/record.url?scp=85089242871&partnerID=8YFLogxK
U2 - 10.1016/j.nima.2020.164493
DO - 10.1016/j.nima.2020.164493
M3 - Article
SN - 0168-9002
VL - 979
JO - Nuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment
JF - Nuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment
M1 - 164493
ER -