Antiviral Activity of Cannabidiolic Acid and Its Methyl Ester against SARS-CoV-2

Martina Tamburello, Stefano Salamone, Lisa Anceschi, Paolo Governa, Virginia Brighenti, Alice Morellini, Giada Rossini, Fabrizio Manetti, Giorgio Gallinella, Federica Pollastro, Federica Pellati

Risultato della ricerca: Contributo su rivistaArticolo in rivistapeer review

Abstract

In the present study, the antiviral activity of cannabinoids isolated from Cannabis sativa L. was assessed in vitro against a panel of SARS-CoV-2 variants, indicating cannabidiolic acid (CBDA) was the most active. To overcome the instability issue of CBDA, its methyl ester was synthesized and tested for the first time for its antiviral activity. CBDA methyl ester showed a neutralizing effect on all the SARS-CoV-2 variants tested with greater activity than the parent compound. Its stability in vitro was confirmed by ultra-high-performance liquid chromatography (UHPLC) analysis coupled with high-resolution mass spectrometry (HRMS). In addition, the capacity of both CBDA and its derivative to interact with the virus spike protein was assessed in silico. These results showed that CBDA methyl ester can be considered as a lead compound to be further developed as a new effective drug against COVID-19 infection.

Lingua originaleInglese
pagine (da-a)1698-1707
Numero di pagine10
RivistaJournal of Natural Products
Volume86
Numero di pubblicazione7
DOI
Stato di pubblicazionePubblicato - 28 lug 2023

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