Antiproliferative effects of daucane esters from Ferula communis and F. arrigonii on human colon cancer cell lines

F. Poli; G. Appendino; G. Sacchetti; M. Ballero; N. Maggiano; F. O. Ranelletti

doi:10.1002/ptr.1443

Antiproliferative effects of daucane esters from Ferula communis and F. arrigonii on human colon cancer cell lines

F. Poli
, G. Appendino
, G. Sacchetti
, M. Ballero
, N. Maggiano
, F. O. Ranelletti

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

Certain jaesekanadiol p-hydroxy- and p-methoxybenzoates - typical of Ferula communis and Ferula arrigonii sardinian plants - show antiproliferative activity on human colon cancer less. The inhibitory doses 50%, calculated after 72 h of treatment, revealed that the antiproliferative capacity of the compounds was in the following descending order: ferutinin > 2α-OH-ferutidin > ferutidin > siol anisate > lapiferin > jaeskeanadiol. Evidence is presented that interaction with type II estrogen-binding sites (EBS) underlies this activity.

Lingua originale	Inglese
pagine (da-a)	152-157
Numero di pagine	6
Rivista	Phytotherapy Research
Volume	19
Numero di pubblicazione	2
DOI	https://doi.org/10.1002/ptr.1443
Stato di pubblicazione	Pubblicato - feb 2005
Pubblicato esternamente	Sì

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title = "Antiproliferative effects of daucane esters from Ferula communis and F. arrigonii on human colon cancer cell lines",

abstract = "Certain jaesekanadiol p-hydroxy- and p-methoxybenzoates - typical of Ferula communis and Ferula arrigonii sardinian plants - show antiproliferative activity on human colon cancer less. The inhibitory doses 50\%, calculated after 72 h of treatment, revealed that the antiproliferative capacity of the compounds was in the following descending order: ferutinin > 2α-OH-ferutidin > ferutidin > siol anisate > lapiferin > jaeskeanadiol. Evidence is presented that interaction with type II estrogen-binding sites (EBS) underlies this activity.",

keywords = "Antiproliferative effects, Binding to Type II EBS, Daucane esters, F. arrigonii, Ferula communis",

author = "F. Poli and G. Appendino and G. Sacchetti and M. Ballero and N. Maggiano and Ranelletti, \{F. O.\}",

year = "2005",

month = feb,

doi = "10.1002/ptr.1443",

language = "English",

volume = "19",

pages = "152--157",

journal = "Phytotherapy Research",

issn = "0951-418X",

publisher = "John Wiley and Sons Ltd",

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TY - JOUR

T1 - Antiproliferative effects of daucane esters from Ferula communis and F. arrigonii on human colon cancer cell lines

AU - Poli, F.

AU - Appendino, G.

AU - Sacchetti, G.

AU - Ballero, M.

AU - Maggiano, N.

AU - Ranelletti, F. O.

PY - 2005/2

Y1 - 2005/2

N2 - Certain jaesekanadiol p-hydroxy- and p-methoxybenzoates - typical of Ferula communis and Ferula arrigonii sardinian plants - show antiproliferative activity on human colon cancer less. The inhibitory doses 50%, calculated after 72 h of treatment, revealed that the antiproliferative capacity of the compounds was in the following descending order: ferutinin > 2α-OH-ferutidin > ferutidin > siol anisate > lapiferin > jaeskeanadiol. Evidence is presented that interaction with type II estrogen-binding sites (EBS) underlies this activity.

AB - Certain jaesekanadiol p-hydroxy- and p-methoxybenzoates - typical of Ferula communis and Ferula arrigonii sardinian plants - show antiproliferative activity on human colon cancer less. The inhibitory doses 50%, calculated after 72 h of treatment, revealed that the antiproliferative capacity of the compounds was in the following descending order: ferutinin > 2α-OH-ferutidin > ferutidin > siol anisate > lapiferin > jaeskeanadiol. Evidence is presented that interaction with type II estrogen-binding sites (EBS) underlies this activity.

KW - Antiproliferative effects

KW - Binding to Type II EBS

KW - Daucane esters

KW - F. arrigonii

KW - Ferula communis

UR - https://www.scopus.com/pages/publications/18444375842

U2 - 10.1002/ptr.1443

DO - 10.1002/ptr.1443

M3 - Article

SN - 0951-418X

VL - 19

SP - 152

EP - 157

JO - Phytotherapy Research

JF - Phytotherapy Research

IS - 2

ER -

Antiproliferative effects of daucane esters from Ferula communis and F. arrigonii on human colon cancer cell lines

Abstract

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