Abstract
Certain jaesekanadiol p-hydroxy- and p-methoxybenzoates - typical of Ferula communis and Ferula arrigonii sardinian plants - show antiproliferative activity on human colon cancer less. The inhibitory doses 50%, calculated after 72 h of treatment, revealed that the antiproliferative capacity of the compounds was in the following descending order: ferutinin > 2α-OH-ferutidin > ferutidin > siol anisate > lapiferin > jaeskeanadiol. Evidence is presented that interaction with type II estrogen-binding sites (EBS) underlies this activity.
Lingua originale | Inglese |
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pagine (da-a) | 152-157 |
Numero di pagine | 6 |
Rivista | Phytotherapy Research |
Volume | 19 |
Numero di pubblicazione | 2 |
DOI | |
Stato di pubblicazione | Pubblicato - feb 2005 |
Pubblicato esternamente | Sì |