TY - JOUR
T1 - Antioxidant activity of capsinoids
AU - Rosa, Antonella
AU - Deiana, Monica
AU - Casu, Viviana
AU - Paccagnini, Stefania
AU - Appendino, Giovanni
AU - Ballero, Mauro
AU - Dessí, M. Assunta
PY - 2002/12/4
Y1 - 2002/12/4
N2 - Hot peppers are a good source of dietary antioxidants, encompassing, apart from widespread compounds (flavonoids, phenolic acids, carotenoids, vitamin A, ascorbic acid, tocopherols), also specific constituents such as the pungent capsaicinoids (capsaicin, dihydrocapsaicin, and related analogues). We have shown that capsinoids also show remarkable antioxidant activity. These benign analogues of capsaicin could protect linoleic acid against free radical attack in simple in vitro systems, inhibiting both its autoxidation and its iron- or EDTA-mediated oxidation. These properties were retained in some simple synthetic analogues (vanillyl nonanoate and its dimerization products). Capsiate, dihydrocapsiate, and their analogues were devoid of pro-oxidant activity and showed a highly significant antioxidant activity in all systems investigated. Vanillyl nonanoate, a simple capsinoid mimic, was also tested on cell cultures for cytotoxic activity and the capacity to inhibit FeCl3-induced oxidation.
AB - Hot peppers are a good source of dietary antioxidants, encompassing, apart from widespread compounds (flavonoids, phenolic acids, carotenoids, vitamin A, ascorbic acid, tocopherols), also specific constituents such as the pungent capsaicinoids (capsaicin, dihydrocapsaicin, and related analogues). We have shown that capsinoids also show remarkable antioxidant activity. These benign analogues of capsaicin could protect linoleic acid against free radical attack in simple in vitro systems, inhibiting both its autoxidation and its iron- or EDTA-mediated oxidation. These properties were retained in some simple synthetic analogues (vanillyl nonanoate and its dimerization products). Capsiate, dihydrocapsiate, and their analogues were devoid of pro-oxidant activity and showed a highly significant antioxidant activity in all systems investigated. Vanillyl nonanoate, a simple capsinoid mimic, was also tested on cell cultures for cytotoxic activity and the capacity to inhibit FeCl3-induced oxidation.
KW - Antioxidants
KW - Capsiate
KW - Capsinoids
KW - Dihydrocapsiate
KW - Linoleic acid oxidation
KW - Vanillyl nonanoate
UR - http://www.scopus.com/inward/record.url?scp=0037021628&partnerID=8YFLogxK
U2 - 10.1021/jf020431w
DO - 10.1021/jf020431w
M3 - Article
SN - 0021-8561
VL - 50
SP - 7396
EP - 7401
JO - Journal of Agricultural and Food Chemistry
JF - Journal of Agricultural and Food Chemistry
IS - 25
ER -