TY - JOUR
T1 - Antiepileptic drugs and mechanisms of epileptogenesis. A review
AU - Mutani, R.
AU - Cantello, R.
AU - Gianelli, M.
AU - Civardi, C.
PY - 1995/4
Y1 - 1995/4
N2 - This paper analyzes the effect of conventional (phenobarbital, phenytoin, carbamazepine, ethosuximide, valproate) and some novel (vigabatrin, lamotrigine, felbamate) AEDs on some basic mechanisms involved in focal and/or generalized epileptogenesis (Na+ voltage-dependent channels and sustained repetitive firing, L-, N-, and T-type Ca2+ currents, GABA-mediated inhibition, Glu/Asp-mediated excitation, after-hyperpolarization). According to this analysis, AEDs can be divided into two main categories, those with only one specific action and those with multiple actions. A speculative correlation is proposed between AED effects on the mechanism of epileptogenesis and their known clinical effect on seizures.
AB - This paper analyzes the effect of conventional (phenobarbital, phenytoin, carbamazepine, ethosuximide, valproate) and some novel (vigabatrin, lamotrigine, felbamate) AEDs on some basic mechanisms involved in focal and/or generalized epileptogenesis (Na+ voltage-dependent channels and sustained repetitive firing, L-, N-, and T-type Ca2+ currents, GABA-mediated inhibition, Glu/Asp-mediated excitation, after-hyperpolarization). According to this analysis, AEDs can be divided into two main categories, those with only one specific action and those with multiple actions. A speculative correlation is proposed between AED effects on the mechanism of epileptogenesis and their known clinical effect on seizures.
KW - antiepileptic drugs
KW - basic mechanisms
KW - epilepsy
UR - http://www.scopus.com/inward/record.url?scp=0029017558&partnerID=8YFLogxK
U2 - 10.1007/BF02282992
DO - 10.1007/BF02282992
M3 - Article
SN - 0392-0461
VL - 16
SP - 217
EP - 222
JO - Neurological Sciences
JF - Neurological Sciences
IS - 3
ER -