Abstract
We have investigated in the present study the effect of Mg2+-valproate on necrotic degeneration induced by an excitotoxic insult in primary culture of cerebellar neurons, that is an homogeneous population of glutamatergic neurons. Mg2+-valproate protected cultures against glutamate-induced neurotoxicity, acting as an indirect N-methyl-D-aspartate (NMDA) receptor antagonist, thus reducing free radical formation and affecting the biochemical parameters (i.e. 45Ca2+-influx, cyclic GMP formation, inositol phospholipid hydrolysis and protein kinase C translocation) that undergo modifications following NMDA receptor activation in cerebellar granule cells.
Lingua originale | Inglese |
---|---|
pagine (da-a) | 121-130 |
Numero di pagine | 10 |
Rivista | Functional Neurology |
Volume | 10 |
Numero di pubblicazione | 3 |
Stato di pubblicazione | Pubblicato - 1995 |
Pubblicato esternamente | Sì |