Antidegenerative effects of Mg2+-valproate in cultured cerebellar neurons

V. Bruno, M. A. Sortino, U. Scapagnini, F. Nicoletti, P. L. Canonico

Risultato della ricerca: Contributo su rivistaArticolo in rivistapeer review

Abstract

We have investigated in the present study the effect of Mg2+-valproate on necrotic degeneration induced by an excitotoxic insult in primary culture of cerebellar neurons, that is an homogeneous population of glutamatergic neurons. Mg2+-valproate protected cultures against glutamate-induced neurotoxicity, acting as an indirect N-methyl-D-aspartate (NMDA) receptor antagonist, thus reducing free radical formation and affecting the biochemical parameters (i.e. 45Ca2+-influx, cyclic GMP formation, inositol phospholipid hydrolysis and protein kinase C translocation) that undergo modifications following NMDA receptor activation in cerebellar granule cells.

Lingua originaleInglese
pagine (da-a)121-130
Numero di pagine10
RivistaFunctional Neurology
Volume10
Numero di pubblicazione3
Stato di pubblicazionePubblicato - 1995
Pubblicato esternamente

Fingerprint

Entra nei temi di ricerca di 'Antidegenerative effects of Mg2+-valproate in cultured cerebellar neurons'. Insieme formano una fingerprint unica.

Cita questo