TY - JOUR
T1 - Antiangiogenic therapies in endometriosis
AU - Ferrero, S.
AU - Ragni, N.
AU - Remorgida, V.
PY - 2006/9/14
Y1 - 2006/9/14
N2 - Oral contraceptives, androgenic agents, progestins and gonadotropin- releasing hormone analogues have all been successfully used in the treatment of endometriosis. However, none of these drugs can eradicate the disease. It is widely accepted that the growth of newly formed blood vessels is essential for the establishment and growth of endometriotic lesions; therefore, inhibition of angiogenesis may offer a new option for treatment of this disorder. In this paper, we reviewed anti-vascular endothelial growth factor agents and other angiostatic drugs (i.e., TNP470, endostatin, anginex, rapamycin) that have been studied in laboratory and animal models of endometriosis. Although preliminary results are interesting, further investigations are required before clinical trials can be planned in humans.
AB - Oral contraceptives, androgenic agents, progestins and gonadotropin- releasing hormone analogues have all been successfully used in the treatment of endometriosis. However, none of these drugs can eradicate the disease. It is widely accepted that the growth of newly formed blood vessels is essential for the establishment and growth of endometriotic lesions; therefore, inhibition of angiogenesis may offer a new option for treatment of this disorder. In this paper, we reviewed anti-vascular endothelial growth factor agents and other angiostatic drugs (i.e., TNP470, endostatin, anginex, rapamycin) that have been studied in laboratory and animal models of endometriosis. Although preliminary results are interesting, further investigations are required before clinical trials can be planned in humans.
KW - Angiogenesis
KW - Endometriosis
KW - Medical treatment
KW - Rapamycin
KW - Vascular endothelial growth factor
UR - http://www.scopus.com/inward/record.url?scp=33748493392&partnerID=8YFLogxK
U2 - 10.1038/sj.bjp.0706860
DO - 10.1038/sj.bjp.0706860
M3 - Review article
SN - 0007-1188
VL - 149
SP - 133
EP - 135
JO - British Journal of Pharmacology
JF - British Journal of Pharmacology
IS - 2
ER -