Anti-Helicobacter pylori agents endowed with H2-antagonist properties

Giovanni Sorba; Massimo Bertinaria; Antonella Di Stilo; Alberto Gasco; Maria M. Scaltrito; Maria I. Brenciaglia; Francesco Dubini

doi:10.1016/S0960-894X(00)00671-5

Anti-Helicobacter pylori agents endowed with H₂-antagonist properties

Giovanni Sorba, Massimo Bertinaria, Antonella Di Stilo, Alberto Gasco, Maria M. Scaltrito, Maria I. Brenciaglia, Francesco Dubini

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

New anti-Helicobacter pylori (H. pylori) agents endowed with H₂-antagonists properties were obtained by combining the lamtidine derived pharmacophoric group with the antibiotic calvatic acid. All the compounds were tested for their irreversible H₂-antagonist properties and for their ability to inhibit 20 H. pylori strains, two of them metronidazole resistant. The most active derivative (compound 4) displayed antimicrobial activity similar to metronidazole.

Lingua originale	Inglese
pagine (da-a)	403-406
Numero di pagine	4
Rivista	Bioorganic and Medicinal Chemistry Letters
Volume	11
Numero di pubblicazione	3
DOI	https://doi.org/10.1016/S0960-894X(00)00671-5
Stato di pubblicazione	Pubblicato - 12 feb 2001
Pubblicato esternamente	Sì

Accesso al documento

10.1016/S0960-894X(00)00671-5

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abstract = "New anti-Helicobacter pylori (H. pylori) agents endowed with H2-antagonists properties were obtained by combining the lamtidine derived pharmacophoric group with the antibiotic calvatic acid. All the compounds were tested for their irreversible H2-antagonist properties and for their ability to inhibit 20 H. pylori strains, two of them metronidazole resistant. The most active derivative (compound 4) displayed antimicrobial activity similar to metronidazole.",

author = "Giovanni Sorba and Massimo Bertinaria and {Di Stilo}, Antonella and Alberto Gasco and Scaltrito, {Maria M.} and Brenciaglia, {Maria I.} and Francesco Dubini",

note = "Funding Information: This work was supported by a grant from MURST, Studi e Ricerche Finalizzate 40%, Roma. ",

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AU - Bertinaria, Massimo

AU - Di Stilo, Antonella

AU - Gasco, Alberto

AU - Scaltrito, Maria M.

AU - Brenciaglia, Maria I.

AU - Dubini, Francesco

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AB - New anti-Helicobacter pylori (H. pylori) agents endowed with H2-antagonists properties were obtained by combining the lamtidine derived pharmacophoric group with the antibiotic calvatic acid. All the compounds were tested for their irreversible H2-antagonist properties and for their ability to inhibit 20 H. pylori strains, two of them metronidazole resistant. The most active derivative (compound 4) displayed antimicrobial activity similar to metronidazole.

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