TY - JOUR
T1 - Angiotensin II specific receptors in subcommissural organ
AU - Ghiani, Pietro
AU - Uva, Biancamaria
AU - Vallarino, Mauro
AU - Mandich, Alberta
AU - Masini, Maria Angela
N1 - Funding Information:
This work was supported by a grant from Ministero della Pubblica Istruzione Italy. Dedicated to Prof. Valdo Mazzi.
PY - 1988/2/29
Y1 - 1988/2/29
N2 - In the subcommissural organ of male rats, a circumventricular organ situated inside the blood-brain barrier, specific receptors for angiotensin II were demonstrated by binding studies on homogenated membranes and by autoradiography carried out on frozen sections using 125I-angiotensin II. The receptor sites were localized in the subnuclear region of cells of the subcommissural organ. A single class of binding sites was found whose capacity was modulated by changes in the sodium plasma concentration which led to variations in plasma volume.
AB - In the subcommissural organ of male rats, a circumventricular organ situated inside the blood-brain barrier, specific receptors for angiotensin II were demonstrated by binding studies on homogenated membranes and by autoradiography carried out on frozen sections using 125I-angiotensin II. The receptor sites were localized in the subnuclear region of cells of the subcommissural organ. A single class of binding sites was found whose capacity was modulated by changes in the sodium plasma concentration which led to variations in plasma volume.
KW - Angiotensin II receptor
KW - Circumventricular organ
KW - Subcommissural organ
UR - http://www.scopus.com/inward/record.url?scp=0023874191&partnerID=8YFLogxK
U2 - 10.1016/0304-3940(88)90353-9
DO - 10.1016/0304-3940(88)90353-9
M3 - Article
SN - 0304-3940
VL - 85
SP - 212
EP - 216
JO - Neuroscience Letters
JF - Neuroscience Letters
IS - 2
ER -