Analysis of pharmaceutically relevant taxoids in wild yew trees from Sardinia

M. Ballero; M. C. Loi; E. L.M. Van Rozendaal; T. A. Van Beek; Cees Van De Haar; F. Poli; G. Appendino

doi:10.1016/S0367-326X(02)00301-5

Analysis of pharmaceutically relevant taxoids in wild yew trees from Sardinia

M. Ballero, M. C. Loi, E. L.M. Van Rozendaal, T. A. Van Beek, Cees Van De Haar, F. Poli, G. Appendino

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

Needles from a series of wild yews (Taxus baccata L.) from Sardinia were investigated for their contents of 10-deacetyl baccatin III (DAB-III, 1), paclitaxel (Taxol^®) (2) and taxine (3). Despite a common geographical origin, ample variation of the taxoid profile was discovered, and several samples were surprisingly devoid of all terpenoid markers above. This finding is unprecedented within the European yew, while the general lack of taxine might rationalize the observation that most plants investigated are actively and impunently browsed by goats.

Lingua originale	Inglese
pagine (da-a)	34-39
Numero di pagine	6
Rivista	Fitoterapia
Volume	74
Numero di pubblicazione	1-2
DOI	https://doi.org/10.1016/S0367-326X(02)00301-5
Stato di pubblicazione	Pubblicato - feb 2003
Pubblicato esternamente	Sì

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10.1016/S0367-326X(02)00301-5

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@article{e95cf5e35db54f63a986fbe0d8e47896,

title = "Analysis of pharmaceutically relevant taxoids in wild yew trees from Sardinia",

abstract = "Needles from a series of wild yews (Taxus baccata L.) from Sardinia were investigated for their contents of 10-deacetyl baccatin III (DAB-III, 1), paclitaxel (Taxol{\textregistered}) (2) and taxine (3). Despite a common geographical origin, ample variation of the taxoid profile was discovered, and several samples were surprisingly devoid of all terpenoid markers above. This finding is unprecedented within the European yew, while the general lack of taxine might rationalize the observation that most plants investigated are actively and impunently browsed by goats.",

keywords = "10-Deacetylbaccatin III, Diterpenoids, Paclitaxel, Taxine, Taxol, Taxus baccata L., Yew",

author = "M. Ballero and Loi, {M. C.} and {Van Rozendaal}, {E. L.M.} and {Van Beek}, {T. A.} and {Van De Haar}, Cees and F. Poli and G. Appendino",

note = "Funding Information: This work was supported by MURST (Fondi ex-40%, Progetto Sostanze Naturali e Analoghi Sintetici con Attivit{\`a} Antitumorale). We are also grateful to Raffaele Sestu and the Pro-Loco Arzana for their help and hospitality during the collection of the samples. ",

year = "2003",

month = feb,

doi = "10.1016/S0367-326X(02)00301-5",

language = "English",

volume = "74",

pages = "34--39",

journal = "Fitoterapia",

issn = "0367-326X",

publisher = "Elsevier B.V.",

number = "1-2",

}

TY - JOUR

T1 - Analysis of pharmaceutically relevant taxoids in wild yew trees from Sardinia

AU - Ballero, M.

AU - Loi, M. C.

AU - Van Rozendaal, E. L.M.

AU - Van Beek, T. A.

AU - Van De Haar, Cees

AU - Poli, F.

AU - Appendino, G.

N1 - Funding Information: This work was supported by MURST (Fondi ex-40%, Progetto Sostanze Naturali e Analoghi Sintetici con Attività Antitumorale). We are also grateful to Raffaele Sestu and the Pro-Loco Arzana for their help and hospitality during the collection of the samples.

PY - 2003/2

Y1 - 2003/2

N2 - Needles from a series of wild yews (Taxus baccata L.) from Sardinia were investigated for their contents of 10-deacetyl baccatin III (DAB-III, 1), paclitaxel (Taxol®) (2) and taxine (3). Despite a common geographical origin, ample variation of the taxoid profile was discovered, and several samples were surprisingly devoid of all terpenoid markers above. This finding is unprecedented within the European yew, while the general lack of taxine might rationalize the observation that most plants investigated are actively and impunently browsed by goats.

AB - Needles from a series of wild yews (Taxus baccata L.) from Sardinia were investigated for their contents of 10-deacetyl baccatin III (DAB-III, 1), paclitaxel (Taxol®) (2) and taxine (3). Despite a common geographical origin, ample variation of the taxoid profile was discovered, and several samples were surprisingly devoid of all terpenoid markers above. This finding is unprecedented within the European yew, while the general lack of taxine might rationalize the observation that most plants investigated are actively and impunently browsed by goats.

KW - 10-Deacetylbaccatin III

KW - Diterpenoids

KW - Paclitaxel

KW - Taxine

KW - Taxol

KW - Taxus baccata L.

KW - Yew

UR - http://www.scopus.com/inward/record.url?scp=0037291481&partnerID=8YFLogxK

U2 - 10.1016/S0367-326X(02)00301-5

DO - 10.1016/S0367-326X(02)00301-5

M3 - Article

SN - 0367-326X

VL - 74

SP - 34

EP - 39

JO - Fitoterapia

JF - Fitoterapia

IS - 1-2

ER -

Analysis of pharmaceutically relevant taxoids in wild yew trees from Sardinia

Abstract

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