Analysis of β1 and β2-adrenergic receptors polymorphism in patients with apical ballooning cardiomyopathy

Olga Vriz, Rosalba Minisini, Rodolfo Citro, Valentina Guerra, Concetta Zito, Giuseppe de Luca, Daniela Pavan, Mario Pirisi, Giuseppe Limongelli, Eduardo Bossone

Risultato della ricerca: Contributo su rivistaArticolo in rivistapeer review

Abstract

Objective The aim of our study was to analyse the frequency of β1 and/or β2 adrenergic receptor polymorphisms in patients with takotsubo cardiomyopathy (TTC). Methods and results β1 and/or β2 adrenergic receptor polymorphisms in 61 patients with TTC were compared with 109 controls. The β1 adrenoreceptor (amino acid position 389) genotype frequencies were significantly different in the two groups; assuming a recessive model for the allelic variant coding for Arg on this position, the odds ratio was 3.14, 95% CI 1.55-6.37 (P = 0.0015). The β2 adrenoreceptor amino acid position 27 genotype was significantly different and assuming a recessive model for the allelic variant coding for Gln on this position, the odds ratio was 0.29, 95% CI 0.12-0.74 (P = 0.009). Conclusions This study showed for the first time an association between TTC phenotype and β1 adrenoreceptor gene polymorphisms. Beta adrenoreceptors gene polymorphisms are probably disease modifiers, and any risk estimate should be based on a combination of genotypes and on interactions with other genes and environmental features.

Lingua originaleInglese
pagine (da-a)787-790
Numero di pagine4
RivistaActa Cardiologica
Volume66
Numero di pubblicazione6
DOI
Stato di pubblicazionePubblicato - 2011

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