An expeditious, multi-gram isolation protocol for the ultrapotent SERCA inhibitor thapsigargin

Alberto Pagani; Federica Pollastro; Silvia Spera; Mauro Ballero; Olov Sterner; Giovanni Appendino

doi:10.1177/1934578x0700200604

An expeditious, multi-gram isolation protocol for the ultrapotent SERCA inhibitor thapsigargin

Alberto Pagani, Federica Pollastro, Silvia Spera, Mauro Ballero, Olov Sterner, Giovanni Appendino

Dipartimento di Scienze del Farmaco

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

A streamlined strategy was developed to obtain a mixture of thapsigargins from the fruits of Thapsia garganica L. The mixture was resolved by RP-silica gel flash chromatography to provide, after trituration with ether, 0.32% thapsigargin (la) as a white powder. A novel, complex phenylpropanoid (neohelmanthicin D, 2a) was also obtained, and its structure confirmed by semisynthesis.

Lingua originale	Inglese
pagine (da-a)	637-642
Numero di pagine	6
Rivista	Natural Product Communications
Volume	2
Numero di pubblicazione	6
DOI	https://doi.org/10.1177/1934578x0700200604
Stato di pubblicazione	Pubblicato - 2007

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10.1177/1934578x0700200604

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abstract = "A streamlined strategy was developed to obtain a mixture of thapsigargins from the fruits of Thapsia garganica L. The mixture was resolved by RP-silica gel flash chromatography to provide, after trituration with ether, 0.32% thapsigargin (la) as a white powder. A novel, complex phenylpropanoid (neohelmanthicin D, 2a) was also obtained, and its structure confirmed by semisynthesis.",

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AU - Sterner, Olov

AU - Appendino, Giovanni

PY - 2007

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AB - A streamlined strategy was developed to obtain a mixture of thapsigargins from the fruits of Thapsia garganica L. The mixture was resolved by RP-silica gel flash chromatography to provide, after trituration with ether, 0.32% thapsigargin (la) as a white powder. A novel, complex phenylpropanoid (neohelmanthicin D, 2a) was also obtained, and its structure confirmed by semisynthesis.

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KW - Thapsigargicin

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An expeditious, multi-gram isolation protocol for the ultrapotent SERCA inhibitor thapsigargin

Abstract

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