An expeditious hydroxyamidation of carboxylic acids

Abdellah Ech-Chahad; Alberto Minassi; Luca Berton; Giovanni Appendino

doi:10.1016/j.tetlet.2005.05.131

An expeditious hydroxyamidation of carboxylic acids

Abdellah Ech-Chahad, Alberto Minassi, Luca Berton, Giovanni Appendino

Dipartimento di Scienze del Farmaco

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

Capitalizing on in situ activation with the cyclic phosphonic anhydride PPAA (1), the conversion of carboxylic acids into hydroxamic acids has been reduced to an experimentally simple one-pot operation that addresses the issue of polyacylation without resorting to a large excess of hydroxylamine or to protection. Scope and selectivity were satisfactory with a wide range of substrates, including α,β-unsaturated acids and hydroxyacids.

Lingua originale	Inglese
pagine (da-a)	5113-5115
Numero di pagine	3
Rivista	Tetrahedron Letters
Volume	46
Numero di pubblicazione	31
DOI	https://doi.org/10.1016/j.tetlet.2005.05.131
Stato di pubblicazione	Pubblicato - 1 ago 2005

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10.1016/j.tetlet.2005.05.131

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title = "An expeditious hydroxyamidation of carboxylic acids",

abstract = "Capitalizing on in situ activation with the cyclic phosphonic anhydride PPAA (1), the conversion of carboxylic acids into hydroxamic acids has been reduced to an experimentally simple one-pot operation that addresses the issue of polyacylation without resorting to a large excess of hydroxylamine or to protection. Scope and selectivity were satisfactory with a wide range of substrates, including α,β-unsaturated acids and hydroxyacids.",

keywords = "Fatty acids, PPAA, Hydroxamic acids, Hydroxyamidation, Oleic acid",

author = "Abdellah Ech-Chahad and Alberto Minassi and Luca Berton and Giovanni Appendino",

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T1 - An expeditious hydroxyamidation of carboxylic acids

AU - Ech-Chahad, Abdellah

AU - Minassi, Alberto

AU - Berton, Luca

AU - Appendino, Giovanni

PY - 2005/8/1

Y1 - 2005/8/1

N2 - Capitalizing on in situ activation with the cyclic phosphonic anhydride PPAA (1), the conversion of carboxylic acids into hydroxamic acids has been reduced to an experimentally simple one-pot operation that addresses the issue of polyacylation without resorting to a large excess of hydroxylamine or to protection. Scope and selectivity were satisfactory with a wide range of substrates, including α,β-unsaturated acids and hydroxyacids.

AB - Capitalizing on in situ activation with the cyclic phosphonic anhydride PPAA (1), the conversion of carboxylic acids into hydroxamic acids has been reduced to an experimentally simple one-pot operation that addresses the issue of polyacylation without resorting to a large excess of hydroxylamine or to protection. Scope and selectivity were satisfactory with a wide range of substrates, including α,β-unsaturated acids and hydroxyacids.

KW - Fatty acids, PPAA

KW - Hydroxamic acids

KW - Hydroxyamidation

KW - Oleic acid

UR - https://www.scopus.com/pages/publications/21344469061

U2 - 10.1016/j.tetlet.2005.05.131

DO - 10.1016/j.tetlet.2005.05.131

M3 - Article

SN - 0040-4039

VL - 46

SP - 5113

EP - 5115

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 31

ER -

An expeditious hydroxyamidation of carboxylic acids

Abstract

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