An esterase-activated magnetic resonance contrast agent

Marco Giardiello; Mark P. Lowe; Mauro Botta

doi:10.1039/b711989e

An esterase-activated magnetic resonance contrast agent

Marco Giardiello
, Mark P. Lowe
, Mauro Botta

Dipartimento di Scienze e Innovazione Tecnologica

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

A Gd(III) complex bearing pendant acetoxymethyl esters is activated on exposure to porcine liver esterase; the 84% increase in relaxivity is a result of suppression of HCO₃^-/CO₃^2- binding by the resulting negative charge.

Lingua originale	Inglese
pagine (da-a)	4044-4046
Numero di pagine	3
Rivista	Chemical Communications
Numero di pubblicazione	39
DOI	https://doi.org/10.1039/b711989e
Stato di pubblicazione	Pubblicato - 2007

Accesso al documento

10.1039/b711989e

Altri file e collegamenti

Link to publication in Scopus

Cita questo

@article{fdf66a8457604505b0860d67634ded19,

title = "An esterase-activated magnetic resonance contrast agent",

abstract = "A Gd(III) complex bearing pendant acetoxymethyl esters is activated on exposure to porcine liver esterase; the 84\% increase in relaxivity is a result of suppression of HCO3-/CO32- binding by the resulting negative charge.",

author = "Marco Giardiello and Lowe, \{Mark P.\} and Mauro Botta",

year = "2007",

doi = "10.1039/b711989e",

language = "English",

pages = "4044--4046",

journal = "Chemical Communications",

issn = "1359-7345",

publisher = "Royal Society of Chemistry",

number = "39",

}

TY - JOUR

T1 - An esterase-activated magnetic resonance contrast agent

AU - Giardiello, Marco

AU - Lowe, Mark P.

AU - Botta, Mauro

PY - 2007

Y1 - 2007

N2 - A Gd(III) complex bearing pendant acetoxymethyl esters is activated on exposure to porcine liver esterase; the 84% increase in relaxivity is a result of suppression of HCO3-/CO32- binding by the resulting negative charge.

AB - A Gd(III) complex bearing pendant acetoxymethyl esters is activated on exposure to porcine liver esterase; the 84% increase in relaxivity is a result of suppression of HCO3-/CO32- binding by the resulting negative charge.

UR - https://www.scopus.com/pages/publications/34948870329

U2 - 10.1039/b711989e

DO - 10.1039/b711989e

M3 - Article

SN - 1359-7345

SP - 4044

EP - 4046

JO - Chemical Communications

JF - Chemical Communications

IS - 39

ER -

An esterase-activated magnetic resonance contrast agent

Abstract

Accesso al documento

Altri file e collegamenti

Fingerprint

Cita questo