An esterase-activated magnetic resonance contrast agent

Marco Giardiello; Mark P. Lowe; Mauro Botta

doi:10.1039/b711989e

An esterase-activated magnetic resonance contrast agent

Marco Giardiello, Mark P. Lowe, Mauro Botta

Dipartimento di Scienze e Innovazione Tecnologica

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

A Gd(III) complex bearing pendant acetoxymethyl esters is activated on exposure to porcine liver esterase; the 84% increase in relaxivity is a result of suppression of HCO₃^-/CO₃^2- binding by the resulting negative charge.

Lingua originale	Inglese
pagine (da-a)	4044-4046
Numero di pagine	3
Rivista	Chemical Communications
Numero di pubblicazione	39
DOI	https://doi.org/10.1039/b711989e
Stato di pubblicazione	Pubblicato - 2007

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10.1039/b711989e

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title = "An esterase-activated magnetic resonance contrast agent",

abstract = "A Gd(III) complex bearing pendant acetoxymethyl esters is activated on exposure to porcine liver esterase; the 84% increase in relaxivity is a result of suppression of HCO3-/CO32- binding by the resulting negative charge.",

author = "Marco Giardiello and Lowe, {Mark P.} and Mauro Botta",

year = "2007",

doi = "10.1039/b711989e",

language = "English",

pages = "4044--4046",

journal = "Chemical Communications",

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publisher = "Royal Society of Chemistry",

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AU - Giardiello, Marco

AU - Lowe, Mark P.

AU - Botta, Mauro

PY - 2007

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AB - A Gd(III) complex bearing pendant acetoxymethyl esters is activated on exposure to porcine liver esterase; the 84% increase in relaxivity is a result of suppression of HCO3-/CO32- binding by the resulting negative charge.

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U2 - 10.1039/b711989e

DO - 10.1039/b711989e

M3 - Article

SN - 1359-7345

SP - 4044

EP - 4046

JO - Chemical Communications

JF - Chemical Communications

IS - 39

ER -

An esterase-activated magnetic resonance contrast agent

Abstract

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