An efficient synthesis of symmetric and unsymmetric bis-(β- aminoamides) via Ugi multicomponent reaction

Fabio La Spisa, Alberto Feo, Riccardo Mossetti, Gian Cesare Tron

Risultato della ricerca: Contributo su rivistaArticolo in rivistapeer review

Abstract

A library of symmetrical and unsymmetrical bis-(β-aminoamides) has been prepared starting from symmetrical secondary diamines by using a double Ugi four-component reaction. A sacrifical Mumm rearrangement, thanks to the use of 2-hydroxymethyl benzoic acid, is necessary to suppress the competing split-Ugi reaction, increasing the yield and simplifying the purification step. The scope, the reaction conditions, and the role of water in trapping the nitrilium intermediate are also discussed.

Lingua originaleInglese
pagine (da-a)6044-6047
Numero di pagine4
RivistaOrganic Letters
Volume14
Numero di pubblicazione23
DOI
Stato di pubblicazionePubblicato - 7 dic 2012

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