Abstract
A library of symmetrical and unsymmetrical bis-(β-aminoamides) has been prepared starting from symmetrical secondary diamines by using a double Ugi four-component reaction. A sacrifical Mumm rearrangement, thanks to the use of 2-hydroxymethyl benzoic acid, is necessary to suppress the competing split-Ugi reaction, increasing the yield and simplifying the purification step. The scope, the reaction conditions, and the role of water in trapping the nitrilium intermediate are also discussed.
Lingua originale | Inglese |
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pagine (da-a) | 6044-6047 |
Numero di pagine | 4 |
Rivista | Organic Letters |
Volume | 14 |
Numero di pubblicazione | 23 |
DOI | |
Stato di pubblicazione | Pubblicato - 7 dic 2012 |