An efficient rose bengal based nanoplatform for photodynamic therapy

Enrica Gianotti; Bianca Martins Estevão; Fabio Cucinotta; Noboru Hioka; Manuela Rizzi; Filippo Renò; Leonardo Marchese

doi:10.1002/chem.201404296

An efficient rose bengal based nanoplatform for photodynamic therapy

Enrica Gianotti
, Bianca Martins Estevão
, Fabio Cucinotta
, Noboru Hioka
, Manuela Rizzi
, Filippo Renò
, Leonardo Marchese

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

Organically modified mesoporous silica nanoparticles (MSNs) containing rose bengal (RB), a xanthene dye, were successfully synthesized. RB-modified MSNs have shown a relevant photostability and a high efficiency in the photoproduction and delivery of singlet oxygen (¹O₂), which is particularly promising for photodynamic therapy (PDT) applications. In vitro tests have evidenced that RB-MSNs are able to reduce cell proliferation in one of the most aggressive skin cancer types (SK-MEL-28) after green-light irradiation.

Lingua originale	Inglese
pagine (da-a)	10921-10925
Numero di pagine	5
Rivista	Chemistry - A European Journal
Volume	20
Numero di pubblicazione	35
DOI	https://doi.org/10.1002/chem.201404296
Stato di pubblicazione	Pubblicato - 25 ago 2014

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title = "An efficient rose bengal based nanoplatform for photodynamic therapy",

abstract = "Organically modified mesoporous silica nanoparticles (MSNs) containing rose bengal (RB), a xanthene dye, were successfully synthesized. RB-modified MSNs have shown a relevant photostability and a high efficiency in the photoproduction and delivery of singlet oxygen (1O2), which is particularly promising for photodynamic therapy (PDT) applications. In vitro tests have evidenced that RB-MSNs are able to reduce cell proliferation in one of the most aggressive skin cancer types (SK-MEL-28) after green-light irradiation.",

keywords = "Rose Bengal, cytotoxicity, mesoporous silica nanoparticles, photodynamic therapy, singlet oxygen",

author = "Enrica Gianotti and \{Martins Estev{\~a}o\}, Bianca and Fabio Cucinotta and Noboru Hioka and Manuela Rizzi and Filippo Ren{\`o} and Leonardo Marchese",

note = "Funding Information: The authors gratefully acknowledge the financial supports of the National Natural Science Foundation of China (No. 21176170).",

year = "2014",

month = aug,

day = "25",

doi = "10.1002/chem.201404296",

language = "English",

volume = "20",

pages = "10921--10925",

journal = "Chemistry - A European Journal",

issn = "0947-6539",

publisher = "Wiley-VCH Verlag",

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TY - JOUR

T1 - An efficient rose bengal based nanoplatform for photodynamic therapy

AU - Gianotti, Enrica

AU - Martins Estevão, Bianca

AU - Cucinotta, Fabio

AU - Hioka, Noboru

AU - Rizzi, Manuela

AU - Renò, Filippo

AU - Marchese, Leonardo

N1 - Funding Information: The authors gratefully acknowledge the financial supports of the National Natural Science Foundation of China (No. 21176170).

PY - 2014/8/25

Y1 - 2014/8/25

N2 - Organically modified mesoporous silica nanoparticles (MSNs) containing rose bengal (RB), a xanthene dye, were successfully synthesized. RB-modified MSNs have shown a relevant photostability and a high efficiency in the photoproduction and delivery of singlet oxygen (1O2), which is particularly promising for photodynamic therapy (PDT) applications. In vitro tests have evidenced that RB-MSNs are able to reduce cell proliferation in one of the most aggressive skin cancer types (SK-MEL-28) after green-light irradiation.

AB - Organically modified mesoporous silica nanoparticles (MSNs) containing rose bengal (RB), a xanthene dye, were successfully synthesized. RB-modified MSNs have shown a relevant photostability and a high efficiency in the photoproduction and delivery of singlet oxygen (1O2), which is particularly promising for photodynamic therapy (PDT) applications. In vitro tests have evidenced that RB-MSNs are able to reduce cell proliferation in one of the most aggressive skin cancer types (SK-MEL-28) after green-light irradiation.

KW - Rose Bengal

KW - cytotoxicity

KW - mesoporous silica nanoparticles

KW - photodynamic therapy

KW - singlet oxygen

UR - https://www.scopus.com/pages/publications/84906781280

U2 - 10.1002/chem.201404296

DO - 10.1002/chem.201404296

M3 - Article

SN - 0947-6539

VL - 20

SP - 10921

EP - 10925

JO - Chemistry - A European Journal

JF - Chemistry - A European Journal

IS - 35

ER -

An efficient rose bengal based nanoplatform for photodynamic therapy

Abstract

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