An alternative synthesis of the breast cancer drug fulvestrant (Faslodex®): catalyst control over C-C bond formation

Diego Caprioglio; Stephen P. Fletcher

doi:10.1039/c5cc05805h

An alternative synthesis of the breast cancer drug fulvestrant (Faslodex®): catalyst control over C-C bond formation

Diego Caprioglio
, Stephen P. Fletcher

Dipartimento di Scienze del Farmaco

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

Fulvestrant (Faslodex®) was synthesized in four steps (35% overall yield) from 6-dehydronandrolone acetate. Catalyst controlled, room temperature, diastereoselective 1,6-addition of the zirconocene derived from commercially available 9-bromonon-1-ene was used in the key C-C bond forming step.

Lingua originale	Inglese
pagine (da-a)	14866-14868
Numero di pagine	3
Rivista	Chemical Communications
Volume	51
Numero di pubblicazione	80
DOI	https://doi.org/10.1039/c5cc05805h
Stato di pubblicazione	Pubblicato - 17 ago 2015

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10.1039/c5cc05805h

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title = "An alternative synthesis of the breast cancer drug fulvestrant (Faslodex{\textregistered}): catalyst control over C-C bond formation",

abstract = "Fulvestrant (Faslodex{\textregistered}) was synthesized in four steps (35\% overall yield) from 6-dehydronandrolone acetate. Catalyst controlled, room temperature, diastereoselective 1,6-addition of the zirconocene derived from commercially available 9-bromonon-1-ene was used in the key C-C bond forming step.",

author = "Diego Caprioglio and Fletcher, \{Stephen P.\}",

note = "Publisher Copyright: {\textcopyright} The Royal Society of Chemistry.",

year = "2015",

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doi = "10.1039/c5cc05805h",

language = "English",

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journal = "Chemical Communications",

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T2 - catalyst control over C-C bond formation

AU - Caprioglio, Diego

AU - Fletcher, Stephen P.

PY - 2015/8/17

Y1 - 2015/8/17

N2 - Fulvestrant (Faslodex®) was synthesized in four steps (35% overall yield) from 6-dehydronandrolone acetate. Catalyst controlled, room temperature, diastereoselective 1,6-addition of the zirconocene derived from commercially available 9-bromonon-1-ene was used in the key C-C bond forming step.

AB - Fulvestrant (Faslodex®) was synthesized in four steps (35% overall yield) from 6-dehydronandrolone acetate. Catalyst controlled, room temperature, diastereoselective 1,6-addition of the zirconocene derived from commercially available 9-bromonon-1-ene was used in the key C-C bond forming step.

UR - https://www.scopus.com/pages/publications/84942427107

U2 - 10.1039/c5cc05805h

DO - 10.1039/c5cc05805h

M3 - Article

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VL - 51

SP - 14866

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JO - Chemical Communications

JF - Chemical Communications

IS - 80

ER -

An alternative synthesis of the breast cancer drug fulvestrant (Faslodex®): catalyst control over C-C bond formation

Abstract

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