An alternative synthesis of the breast cancer drug fulvestrant (Faslodex®): catalyst control over C-C bond formation

Diego Caprioglio; Stephen P. Fletcher

doi:10.1039/c5cc05805h

An alternative synthesis of the breast cancer drug fulvestrant (Faslodex®): catalyst control over C-C bond formation

Diego Caprioglio, Stephen P. Fletcher

Dipartimento di Scienze del Farmaco

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

Fulvestrant (Faslodex®) was synthesized in four steps (35% overall yield) from 6-dehydronandrolone acetate. Catalyst controlled, room temperature, diastereoselective 1,6-addition of the zirconocene derived from commercially available 9-bromonon-1-ene was used in the key C-C bond forming step.

Lingua originale	Inglese
pagine (da-a)	14866-14868
Numero di pagine	3
Rivista	Chemical Communications
Volume	51
Numero di pubblicazione	80
DOI	https://doi.org/10.1039/c5cc05805h
Stato di pubblicazione	Pubblicato - 17 ago 2015

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title = "An alternative synthesis of the breast cancer drug fulvestrant (Faslodex{\textregistered}): catalyst control over C-C bond formation",

abstract = "Fulvestrant (Faslodex{\textregistered}) was synthesized in four steps (35% overall yield) from 6-dehydronandrolone acetate. Catalyst controlled, room temperature, diastereoselective 1,6-addition of the zirconocene derived from commercially available 9-bromonon-1-ene was used in the key C-C bond forming step.",

author = "Diego Caprioglio and Fletcher, {Stephen P.}",

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AB - Fulvestrant (Faslodex®) was synthesized in four steps (35% overall yield) from 6-dehydronandrolone acetate. Catalyst controlled, room temperature, diastereoselective 1,6-addition of the zirconocene derived from commercially available 9-bromonon-1-ene was used in the key C-C bond forming step.

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An alternative synthesis of the breast cancer drug fulvestrant (Faslodex®): catalyst control over C-C bond formation

Abstract

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