Keyphrases
Antiproliferative Activity
100%
N-terminal Loop
100%
Human Dihydroorotate Dehydrogenase (hDHODH)
100%
Alternative Conformations
100%
Drug Design
66%
Antiretroviral Therapy
33%
Hydrophobicity
33%
Water Molecule
33%
Hydrogen Bonds (H-bonds)
33%
Acute Myeloid Leukemia
33%
Autoimmune Disease
33%
X-ray Crystallography
33%
Thermodynamics
33%
Pharmacophore
33%
Structural Insights
33%
Molecular Modeling
33%
Pyridine
33%
Water Solubility
33%
Binding Pocket
33%
In Vivo Efficacy
33%
Potent Inhibitor
33%
Solvent Molecules
33%
Pyridine Moiety
33%
Membrane Permeable
33%
Inhibitor Binding
33%
Innovative Drugs
33%
Drug-like
33%
Binding Behavior
33%
Pyrimidine Biosynthesis
33%
Pyrimidine Biosynthesis Pathway
33%
Protein Loops
33%
Host-targeted Antiviral
33%
Cofactor-binding Site
33%
LogD7.4
33%
Gating Mechanism
33%
Binding Pose
33%
Isothermal Titration Calorimetry
33%
Biochemistry, Genetics and Molecular Biology
Conformation
100%
N-Terminus
100%
Drive
100%
Dihydroorotate Dehydrogenase
100%
Binding Site
33%
Pharmacophore
33%
Molecular Model
33%
Crystal Structure
33%
Dynamics
33%
X-Ray Crystallography
33%
Hydrophobicity
33%
Hydrogen Bond
33%
Pyrimidine Biosynthesis
33%
Isothermal Titration Calorimetry
33%
Chemistry
Antiproliferative
100%
Dihydroorotate
100%
Hydrophobicity
33%
Kd
33%
Crystal Structure
33%
Binding Site
33%
X-Ray Crystallography
33%
Isothermal Titration Calorimetry
33%
formation
33%
Hydrogen Bond
33%
Molecular Model
33%
Cofactor
33%
Pharmacology, Toxicology and Pharmaceutical Science
Dihydroorotate Dehydrogenase
100%
Drug Development
66%
Hydrophobicity
33%
Acute Myeloid Leukemia
33%
Binding Site
33%
Antiviral Therapy
33%
Autoimmune Disease
33%
Calorimetry
33%
Hydrogen Bond
33%