Amphiphilic Ditopic Bis-Aqua Gd-AAZTA-like Complexes Enhance Relaxivity of Lipidic MRI Nanoprobes

Risultato della ricerca: Contributo su rivistaArticolo in rivistapeer review

Abstract

Two amphiphilic mono- and dimeric GdAAZTA-like chelates composed of stable bis-aquo GdIII complexes (q=2) linked to one (for the monomer) or two dodecyl aliphatic chains (for the dimer) were synthesized. Both chelates showed high relaxivity when incorporated into the lipid bilayer of liposomes or after interaction with human serum albumin (HSA). The ditopic complex shows a significantly decreased internal motion relative to the monomeric complex, associated with an enhanced relaxivity (r1≈60 mm−1 s−1, at 30 MHz and 310 K). The presence of two metal-bound water molecules in fast exchange and the restricted rotational freedom make the relaxivity of this system the highest measured for paramagnetic liposomes.

Lingua originaleInglese
pagine (da-a)2139-2143
Numero di pagine5
RivistaChemistry - An Asian Journal
Volume11
Numero di pubblicazione15
DOI
Stato di pubblicazionePubblicato - 5 ago 2016

Fingerprint

Entra nei temi di ricerca di 'Amphiphilic Ditopic Bis-Aqua Gd-AAZTA-like Complexes Enhance Relaxivity of Lipidic MRI Nanoprobes'. Insieme formano una fingerprint unica.

Cita questo