Ammonium chloride promoted three-component synthesis of 5-iminooxazoline and its subsequent transformation to macrocyclodepsipeptide

Tracey Pirali; Gian Cesare Tron; Géraldine Masson; Jieping Zhu

doi:10.1021/ol7024372

Ammonium chloride promoted three-component synthesis of 5-iminooxazoline and its subsequent transformation to macrocyclodepsipeptide

Tracey Pirali
, Gian Cesare Tron
, Géraldine Masson
, Jieping Zhu

Dipartimento di Scienze del Farmaco

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

(Chemical Equation Presented) A three-component reaction of an α,α-disubstituted α-isocyanoacetamide, an aldehyde and an amino alcohol afforded the 5-iminooxazoline, which, upon saponification, cyclized under acidic conditions to provide the macrocyclodepsipeptide in good overall yield.

Lingua originale	Inglese
pagine (da-a)	5275-5278
Numero di pagine	4
Rivista	Organic Letters
Volume	9
Numero di pubblicazione	25
DOI	https://doi.org/10.1021/ol7024372
Stato di pubblicazione	Pubblicato - 6 dic 2007

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10.1021/ol7024372

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@article{ef25b6caa56d48f886306ec71e6d94a9,

title = "Ammonium chloride promoted three-component synthesis of 5-iminooxazoline and its subsequent transformation to macrocyclodepsipeptide",

abstract = "(Chemical Equation Presented) A three-component reaction of an α,α-disubstituted α-isocyanoacetamide, an aldehyde and an amino alcohol afforded the 5-iminooxazoline, which, upon saponification, cyclized under acidic conditions to provide the macrocyclodepsipeptide in good overall yield.",

author = "Tracey Pirali and Tron, \{Gian Cesare\} and G{\'e}raldine Masson and Jieping Zhu",

year = "2007",

month = dec,

day = "6",

doi = "10.1021/ol7024372",

language = "English",

volume = "9",

pages = "5275--5278",

journal = "Organic Letters",

issn = "1523-7060",

publisher = "American Chemical Society",

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TY - JOUR

T1 - Ammonium chloride promoted three-component synthesis of 5-iminooxazoline and its subsequent transformation to macrocyclodepsipeptide

AU - Pirali, Tracey

AU - Tron, Gian Cesare

AU - Masson, Géraldine

AU - Zhu, Jieping

PY - 2007/12/6

Y1 - 2007/12/6

N2 - (Chemical Equation Presented) A three-component reaction of an α,α-disubstituted α-isocyanoacetamide, an aldehyde and an amino alcohol afforded the 5-iminooxazoline, which, upon saponification, cyclized under acidic conditions to provide the macrocyclodepsipeptide in good overall yield.

AB - (Chemical Equation Presented) A three-component reaction of an α,α-disubstituted α-isocyanoacetamide, an aldehyde and an amino alcohol afforded the 5-iminooxazoline, which, upon saponification, cyclized under acidic conditions to provide the macrocyclodepsipeptide in good overall yield.

UR - https://www.scopus.com/pages/publications/37249023613

U2 - 10.1021/ol7024372

DO - 10.1021/ol7024372

M3 - Article

SN - 1523-7060

VL - 9

SP - 5275

EP - 5278

JO - Organic Letters

JF - Organic Letters

IS - 25

ER -

Ammonium chloride promoted three-component synthesis of 5-iminooxazoline and its subsequent transformation to macrocyclodepsipeptide

Abstract

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