Alzheimer's disease linking neurodegeneration with neurodevelopment

Mariagrazia Grilli, Giulia Ferrari Toninelli, Daniela Uberti, Pier Franco Spano, Maurizio Memo

Risultato della ricerca: Contributo su rivistaArticolo di reviewpeer review

Abstract

An association has recently been suggested between several of the genes and proteins that play a central role in early neuronal development, particularly in neuronal migration and axon elongation, and Alzheimer's disease (AD). This paper reviews the work of several investigators who have hypothesised the involvement of three pathways known to be active participants in neuronal maturation (those involving Notch, Reelin, and Wnt intracellular signalling) and also in the neurodegenerative events underlying AD. The choice of these intracellular pathways is based on the observation that there exist several points of convergence among these systems and amyloid precursor protein processing and neurofibrillary tangle formation. Pharmacological manipulation of the Notch/Wnt/Reelin intracellular signalling pathways may thus represent a novel approach to the regulation of neurodegenerative processes in AD.

Lingua originaleInglese
pagine (da-a)145-148
Numero di pagine4
RivistaFunctional Neurology
Volume18
Numero di pubblicazione3
Stato di pubblicazionePubblicato - lug 2003
Pubblicato esternamente

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