Allopurinol protects against manganese-induced oxidative stress in the striatum and in the brainstem of the rat

M. S. Desole, G. Esposito, R. Migheli, L. Fresu, S. Sircana, M. Miele, G. De Natale, E. Miele

Risultato della ricerca: Contributo su rivistaArticolo in rivistapeer review

Abstract

Levels of uric acid, xanthine, hypoxanthine, ascorbic acid (AA), dehydroascorbic acid, glutathione (GSH), noradrenaline (NA), dopamine (DA), dihydroxyphenylacetic acid (DOPAC), homovanillic acid (HVA) and 3-methoxytyramine were determined in the striatum and/or in the brainstem of 3-month-old male Wistar rats given manganese (MnCl2, 200 mg/kg/day for 7 days by gavage) alone or associated with allopurinol. Allopurinol alone (300 mg/kg/day for 4 days by gavage) decreased uric acid and increased xanthine levels both in the striatum and in the brainstem; moreover, allopurinol decreased the striatal DOPAC + HVA/DA ratio. Allopurinol antagonised the Mn-induced: (a) increase in the DOPAC + HVA/DA ratio; (b) increase in uric acid levels and AA oxidation; and (c) decrease in GSH and NA levels. We conclude that allopurinol may protect against Mn-induced oxidative stress by inhibiting both DA oxidative metabolism and xanthine oxidase-mediated formation of reactive oxygen species.

Lingua originaleInglese
pagine (da-a)73-76
Numero di pagine4
RivistaNeuroscience Letters
Volume192
Numero di pubblicazione2
DOI
Stato di pubblicazionePubblicato - 9 giu 1995
Pubblicato esternamente

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