Allogeneic stem cell transplantation in mantle cell lymphoma in the era of new drugs and CAR-T cell therapy

Miriam Marangon; Carlo Visco; Anna Maria Barbui; Annalisa Chiappella; Alberto Fabbri; Simone Ferrero; Sara Galimberti; Stefano Luminari; Gerardo Musuraca; Alessandro Re; Vittorio Ruggero Zilioli; Marco Ladetto

doi:10.3390/cancers13020291

Allogeneic stem cell transplantation in mantle cell lymphoma in the era of new drugs and CAR-T cell therapy

Miriam Marangon, Carlo Visco, Anna Maria Barbui, Annalisa Chiappella, Alberto Fabbri, Simone Ferrero, Sara Galimberti, Stefano Luminari, Gerardo Musuraca, Alessandro Re, Vittorio Ruggero Zilioli, Marco Ladetto

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

MCL is an uncommon lymphoproliferative disorder that has been regarded as incurable since its identification as a distinct entity. Allogeneic transplantation for two decades has represented the only option capable of ensuring prolonged remissions and possibly cure. Despite its efficacy, its application has been limited by feasibility limitations and substantial toxicity, particularly in elderly patients. Nevertheless, the experience accumulated over time has been wide though often scattered among retrospective and small prospective studies. In this review, we aimed at critically revise and discuss available evidence on allogeneic transplantation in MCL, trying to put available evidence into the 2020 perspective, characterized by unprecedented development of novel promising therapeutic agents and regimens.

Lingua originale	Inglese
Numero di articolo	291
pagine (da-a)	1-21
Numero di pagine	21
Rivista	Cancers
Volume	13
Numero di pubblicazione	2
DOI	https://doi.org/10.3390/cancers13020291
Stato di pubblicazione	Pubblicato - 2 gen 2021
Pubblicato esternamente	Sì

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10.3390/cancers13020291

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title = "Allogeneic stem cell transplantation in mantle cell lymphoma in the era of new drugs and CAR-T cell therapy",

abstract = "MCL is an uncommon lymphoproliferative disorder that has been regarded as incurable since its identification as a distinct entity. Allogeneic transplantation for two decades has represented the only option capable of ensuring prolonged remissions and possibly cure. Despite its efficacy, its application has been limited by feasibility limitations and substantial toxicity, particularly in elderly patients. Nevertheless, the experience accumulated over time has been wide though often scattered among retrospective and small prospective studies. In this review, we aimed at critically revise and discuss available evidence on allogeneic transplantation in MCL, trying to put available evidence into the 2020 perspective, characterized by unprecedented development of novel promising therapeutic agents and regimens.",

keywords = "Allogeneic stem cell transplantation, Car-T cell therapy, Mantle cell lymphoma",

author = "Miriam Marangon and Carlo Visco and Barbui, {Anna Maria} and Annalisa Chiappella and Alberto Fabbri and Simone Ferrero and Sara Galimberti and Stefano Luminari and Gerardo Musuraca and Alessandro Re and Zilioli, {Vittorio Ruggero} and Marco Ladetto",

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T1 - Allogeneic stem cell transplantation in mantle cell lymphoma in the era of new drugs and CAR-T cell therapy

AU - Marangon, Miriam

AU - Visco, Carlo

AU - Barbui, Anna Maria

AU - Chiappella, Annalisa

AU - Fabbri, Alberto

AU - Ferrero, Simone

AU - Galimberti, Sara

AU - Luminari, Stefano

AU - Musuraca, Gerardo

AU - Re, Alessandro

AU - Zilioli, Vittorio Ruggero

AU - Ladetto, Marco

PY - 2021/1/2

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N2 - MCL is an uncommon lymphoproliferative disorder that has been regarded as incurable since its identification as a distinct entity. Allogeneic transplantation for two decades has represented the only option capable of ensuring prolonged remissions and possibly cure. Despite its efficacy, its application has been limited by feasibility limitations and substantial toxicity, particularly in elderly patients. Nevertheless, the experience accumulated over time has been wide though often scattered among retrospective and small prospective studies. In this review, we aimed at critically revise and discuss available evidence on allogeneic transplantation in MCL, trying to put available evidence into the 2020 perspective, characterized by unprecedented development of novel promising therapeutic agents and regimens.

AB - MCL is an uncommon lymphoproliferative disorder that has been regarded as incurable since its identification as a distinct entity. Allogeneic transplantation for two decades has represented the only option capable of ensuring prolonged remissions and possibly cure. Despite its efficacy, its application has been limited by feasibility limitations and substantial toxicity, particularly in elderly patients. Nevertheless, the experience accumulated over time has been wide though often scattered among retrospective and small prospective studies. In this review, we aimed at critically revise and discuss available evidence on allogeneic transplantation in MCL, trying to put available evidence into the 2020 perspective, characterized by unprecedented development of novel promising therapeutic agents and regimens.

KW - Allogeneic stem cell transplantation

KW - Car-T cell therapy

KW - Mantle cell lymphoma

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U2 - 10.3390/cancers13020291

DO - 10.3390/cancers13020291

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ER -

Allogeneic stem cell transplantation in mantle cell lymphoma in the era of new drugs and CAR-T cell therapy

Abstract

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