TY - JOUR
T1 - Alcohol consumption and the risk for prostate cancer in the european prospective investigation into cancer and nutrition
AU - Rohrmann, Sabine
AU - Linseisen, Jakob
AU - Key, Timothy J.
AU - Jensen, Majken K.
AU - Overvad, Kim
AU - Johnsen, Nina Føns
AU - Tjønneland, Anne
AU - Kaaks, Rudolf
AU - Bergmann, Manuela M.
AU - Weikert, Cornelia
AU - Naska, Androniki
AU - Trichopoulou, Antonia
AU - Trichopoulos, Dimitrios
AU - Pala, Valeria
AU - Sacerdote, Carlotta
AU - Palli, Domenico
AU - Tumino, Rosario
AU - Bueno-de-Mesquita, H. Bas
AU - Vrieling, Alina
AU - González, Carlos A.
AU - Larrañaga, Nerea
AU - Navarro, Carmen
AU - Barricarte, Aurelio
AU - Quiros, J. Ramon
AU - Martínez-García, Carmen
AU - Hallmans, Göran
AU - Stattin, Pär
AU - Manjer, Jonas
AU - Wirfält, Elisabet
AU - Bingham, Sheila
AU - Khaw, Key Tee
AU - Egevad, Lars
AU - Ferrari, Pietro
AU - Jenab, Mazda
AU - Riboli, Elio
PY - 2008/5
Y1 - 2008/5
N2 - Alcohol is a risk factor for several types of cancer. However, the results for prostate cancer have been inconsistent, with most studies showing no association. Within the European Prospective Investigation into Cancer and Nutrition, detailed information were collected from 142,607 male participants on the intake of alcoholic beverages at recruitment (for 100% of the cohort) and over lifetime (for 76% of the cohort) between 1992 and 2000. During a median follow-up of 8.7 years, 2,655 prostate cancer cases were observed. Multivariate Cox proportional hazard models were used to examine the association of alcohol consumption at recruitment and average lifetime alcohol consumption with prostate cancer adjusted for age, center, smoking, height, weight, physical activity, and nonalcohol energy intake. Overall, neither alcohol consumption at baseline nor average lifetime alcohol consumption was associated with the risk for prostate cancer in this cohort of men. Men who consumed ≥60 g alcohol per day had a relative risk of 0.88 [95% confidence interval (95% CI) 0.72-1.08] compared with men with an intake of 0.1-4.9 g/d; the respective relative risk for average lifetime intake was 1.09 (95% CI, 0.86-1.39). For advanced prostate cancer (n = 537), the relative risks for ≥60 and 0.1-4.9 g alcohol per day at baseline were 0.98 (95% CI, 0.66-1.44) and 1.28 (95% CI, 0.79-2-07), respectively, for average lifetime intake. No statistically significant association was observed for alcohol intake from specific alcoholic beverages. Our results indicate no association between the consumption of alcohol and prostate cancer in this cohort of European men.
AB - Alcohol is a risk factor for several types of cancer. However, the results for prostate cancer have been inconsistent, with most studies showing no association. Within the European Prospective Investigation into Cancer and Nutrition, detailed information were collected from 142,607 male participants on the intake of alcoholic beverages at recruitment (for 100% of the cohort) and over lifetime (for 76% of the cohort) between 1992 and 2000. During a median follow-up of 8.7 years, 2,655 prostate cancer cases were observed. Multivariate Cox proportional hazard models were used to examine the association of alcohol consumption at recruitment and average lifetime alcohol consumption with prostate cancer adjusted for age, center, smoking, height, weight, physical activity, and nonalcohol energy intake. Overall, neither alcohol consumption at baseline nor average lifetime alcohol consumption was associated with the risk for prostate cancer in this cohort of men. Men who consumed ≥60 g alcohol per day had a relative risk of 0.88 [95% confidence interval (95% CI) 0.72-1.08] compared with men with an intake of 0.1-4.9 g/d; the respective relative risk for average lifetime intake was 1.09 (95% CI, 0.86-1.39). For advanced prostate cancer (n = 537), the relative risks for ≥60 and 0.1-4.9 g alcohol per day at baseline were 0.98 (95% CI, 0.66-1.44) and 1.28 (95% CI, 0.79-2-07), respectively, for average lifetime intake. No statistically significant association was observed for alcohol intake from specific alcoholic beverages. Our results indicate no association between the consumption of alcohol and prostate cancer in this cohort of European men.
UR - https://www.scopus.com/pages/publications/52649144323
U2 - 10.1158/1055-9965.EPI-07-2888
DO - 10.1158/1055-9965.EPI-07-2888
M3 - Article
SN - 1055-9965
VL - 17
SP - 1282
EP - 1287
JO - Cancer Epidemiology Biomarkers and Prevention
JF - Cancer Epidemiology Biomarkers and Prevention
IS - 5
ER -
