Alcohol Consumption and Risk of Parkinson's Disease: Data From a Large Prospective European Cohort

Susan Peters; Valentina Gallo; Paolo Vineis; Lefkos T. Middleton; Lars Forsgren; Carlotta Sacerdote; Sabina Sieri; Andreas Kyrozis; María Dolores Chirlaque; Raul Zamora-Ros; Oskar Hansson; Jesper Petersson; Verena Katzke; Tilman Kühn; Olatz Mokoroa; Giovanna Masala; Eva Ardanaz; Salvatore Panico; Manuela M. Bergmann; Timothy J. Key; Elisabete Weiderpass; Pietro Ferrari; Roel Vermeulen

doi:10.1002/mds.28039

Alcohol Consumption and Risk of Parkinson's Disease: Data From a Large Prospective European Cohort

Susan Peters, Valentina Gallo, Paolo Vineis, Lefkos T. Middleton, Lars Forsgren, Carlotta Sacerdote, Sabina Sieri, Andreas Kyrozis, María Dolores Chirlaque, Raul Zamora-Ros, Oskar Hansson, Jesper Petersson, Verena Katzke, Tilman Kühn, Olatz Mokoroa, Giovanna Masala, Eva Ardanaz, Salvatore Panico, Manuela M. Bergmann, Timothy J. KeyElisabete Weiderpass, Pietro Ferrari, Roel Vermeulen

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

Background: Parkinson's disease (PD) etiology is not well understood. Reported inverse associations with smoking and coffee consumption prompted the investigation of alcohol consumption as a risk factor, for which evidence is inconclusive. Objective: To assess the associations between alcohol consumption and PD risk. Methods: Within NeuroEPIC4PD, a prospective European population-based cohort, 694 incident PD cases were ascertained from 209,998 PD-free participants. Average alcohol consumption at different time points was self-reported at recruitment. Cox regression hazard ratios were estimated for alcohol consumption and PD occurrence. Results: No associations between baseline or lifetime total alcohol consumption and PD risk were observed. Men with moderate lifetime consumption (5–29.9 g/day) were at ~50% higher risk compared with light consumption (0.1–4.9 g/day), but no linear exposure–response trend was observed. Analyses by beverage type also revealed no associations with PD. Conclusion: Our data reinforce previous findings from prospective studies showing no association between alcohol consumption and PD risk.

Lingua originale	Inglese
pagine (da-a)	1258-1263
Numero di pagine	6
Rivista	Movement Disorders
Volume	35
Numero di pubblicazione	7
DOI	https://doi.org/10.1002/mds.28039
Stato di pubblicazione	Pubblicato - 1 lug 2020
Pubblicato esternamente	Sì

Accesso al documento

10.1002/mds.28039

Altri file e collegamenti

Link to publication in Scopus

Cita questo

Peters, S., Gallo, V., Vineis, P., Middleton, L. T., Forsgren, L., Sacerdote, C., Sieri, S., Kyrozis, A., Chirlaque, M. D., Zamora-Ros, R., Hansson, O., Petersson, J., Katzke, V., Kühn, T., Mokoroa, O., Masala, G., Ardanaz, E., Panico, S., Bergmann, M. M., ... Vermeulen, R. (2020). Alcohol Consumption and Risk of Parkinson's Disease: Data From a Large Prospective European Cohort. Movement Disorders, 35(7), 1258-1263. https://doi.org/10.1002/mds.28039

@article{565f5fa8c1d8433480353654a08a4a91,

title = "Alcohol Consumption and Risk of Parkinson's Disease: Data From a Large Prospective European Cohort",

abstract = "Background: Parkinson's disease (PD) etiology is not well understood. Reported inverse associations with smoking and coffee consumption prompted the investigation of alcohol consumption as a risk factor, for which evidence is inconclusive. Objective: To assess the associations between alcohol consumption and PD risk. Methods: Within NeuroEPIC4PD, a prospective European population-based cohort, 694 incident PD cases were ascertained from 209,998 PD-free participants. Average alcohol consumption at different time points was self-reported at recruitment. Cox regression hazard ratios were estimated for alcohol consumption and PD occurrence. Results: No associations between baseline or lifetime total alcohol consumption and PD risk were observed. Men with moderate lifetime consumption (5–29.9 g/day) were at \textasciitilde{}50\% higher risk compared with light consumption (0.1–4.9 g/day), but no linear exposure–response trend was observed. Analyses by beverage type also revealed no associations with PD. Conclusion: Our data reinforce previous findings from prospective studies showing no association between alcohol consumption and PD risk.",

keywords = "EPIC, Parkinson, alcohol, epidemiology, prospective cohort",

author = "Susan Peters and Valentina Gallo and Paolo Vineis and Middleton, \{Lefkos T.\} and Lars Forsgren and Carlotta Sacerdote and Sabina Sieri and Andreas Kyrozis and Chirlaque, \{Mar{\'i}a Dolores\} and Raul Zamora-Ros and Oskar Hansson and Jesper Petersson and Verena Katzke and Tilman K{\"u}hn and Olatz Mokoroa and Giovanna Masala and Eva Ardanaz and Salvatore Panico and Bergmann, \{Manuela M.\} and Key, \{Timothy J.\} and Elisabete Weiderpass and Pietro Ferrari and Roel Vermeulen",

note = "Publisher Copyright: {\textcopyright} 2020 The Authors. Movement Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society.",

year = "2020",

month = jul,

day = "1",

doi = "10.1002/mds.28039",

language = "English",

volume = "35",

pages = "1258--1263",

journal = "Movement Disorders",

issn = "0885-3185",

publisher = "John Wiley \& Sons Inc.",

number = "7",

}

Peters, S, Gallo, V, Vineis, P, Middleton, LT, Forsgren, L, Sacerdote, C, Sieri, S, Kyrozis, A, Chirlaque, MD, Zamora-Ros, R, Hansson, O, Petersson, J, Katzke, V, Kühn, T, Mokoroa, O, Masala, G, Ardanaz, E, Panico, S, Bergmann, MM, Key, TJ, Weiderpass, E, Ferrari, P & Vermeulen, R 2020, 'Alcohol Consumption and Risk of Parkinson's Disease: Data From a Large Prospective European Cohort', Movement Disorders, vol. 35, n. 7, pagg. 1258-1263. https://doi.org/10.1002/mds.28039

TY - JOUR

T1 - Alcohol Consumption and Risk of Parkinson's Disease

T2 - Data From a Large Prospective European Cohort

AU - Peters, Susan

AU - Gallo, Valentina

AU - Vineis, Paolo

AU - Middleton, Lefkos T.

AU - Forsgren, Lars

AU - Sacerdote, Carlotta

AU - Sieri, Sabina

AU - Kyrozis, Andreas

AU - Chirlaque, María Dolores

AU - Zamora-Ros, Raul

AU - Hansson, Oskar

AU - Petersson, Jesper

AU - Katzke, Verena

AU - Kühn, Tilman

AU - Mokoroa, Olatz

AU - Masala, Giovanna

AU - Ardanaz, Eva

AU - Panico, Salvatore

AU - Bergmann, Manuela M.

AU - Key, Timothy J.

AU - Weiderpass, Elisabete

AU - Ferrari, Pietro

AU - Vermeulen, Roel

PY - 2020/7/1

Y1 - 2020/7/1

N2 - Background: Parkinson's disease (PD) etiology is not well understood. Reported inverse associations with smoking and coffee consumption prompted the investigation of alcohol consumption as a risk factor, for which evidence is inconclusive. Objective: To assess the associations between alcohol consumption and PD risk. Methods: Within NeuroEPIC4PD, a prospective European population-based cohort, 694 incident PD cases were ascertained from 209,998 PD-free participants. Average alcohol consumption at different time points was self-reported at recruitment. Cox regression hazard ratios were estimated for alcohol consumption and PD occurrence. Results: No associations between baseline or lifetime total alcohol consumption and PD risk were observed. Men with moderate lifetime consumption (5–29.9 g/day) were at ~50% higher risk compared with light consumption (0.1–4.9 g/day), but no linear exposure–response trend was observed. Analyses by beverage type also revealed no associations with PD. Conclusion: Our data reinforce previous findings from prospective studies showing no association between alcohol consumption and PD risk.

AB - Background: Parkinson's disease (PD) etiology is not well understood. Reported inverse associations with smoking and coffee consumption prompted the investigation of alcohol consumption as a risk factor, for which evidence is inconclusive. Objective: To assess the associations between alcohol consumption and PD risk. Methods: Within NeuroEPIC4PD, a prospective European population-based cohort, 694 incident PD cases were ascertained from 209,998 PD-free participants. Average alcohol consumption at different time points was self-reported at recruitment. Cox regression hazard ratios were estimated for alcohol consumption and PD occurrence. Results: No associations between baseline or lifetime total alcohol consumption and PD risk were observed. Men with moderate lifetime consumption (5–29.9 g/day) were at ~50% higher risk compared with light consumption (0.1–4.9 g/day), but no linear exposure–response trend was observed. Analyses by beverage type also revealed no associations with PD. Conclusion: Our data reinforce previous findings from prospective studies showing no association between alcohol consumption and PD risk.

KW - EPIC

KW - Parkinson

KW - alcohol

KW - epidemiology

KW - prospective cohort

UR - https://www.scopus.com/pages/publications/85084214967

U2 - 10.1002/mds.28039

DO - 10.1002/mds.28039

M3 - Article

SN - 0885-3185

VL - 35

SP - 1258

EP - 1263

JO - Movement Disorders

JF - Movement Disorders

IS - 7

ER -

Alcohol Consumption and Risk of Parkinson's Disease: Data From a Large Prospective European Cohort

Abstract

Accesso al documento

Altri file e collegamenti

Fingerprint

Cita questo