Aids-related plasmablastic lymphomas of the oral cavity and jaws: A diagnostic dilemma

Antonino Carbone, Alfio Ferlito, Gianluca Gaidano, Alessandra Rinaldo, Annunziata Gloghini, Harald Stein

Risultato della ricerca: Contributo su rivistaArticolo in rivistapeer review

Abstract

Acquired immunodeficiency syndrome (AIDS)-related non-Hodgkin's lymphomas are highly pleomorphic in their clinical, pathological, and biological features. Recent investigations have led to the identification of a particular type of AIDS-related non-Hodgkin's lymphomas presenting in the oral cavity and jaws. This novel category of AIDS-related non-Hodgkin's lymphomas derives from B-cells and has been defined as plasmablastic lymphoma on the basis of its morphological and immunophenotypic features. Clinically, AIDS-related plasmablastic lymphoma is generally limited to the oral cavity at the time of diagnosis, although extension to distant sites frequently occurs at a later stage. Histologically, AIDS-related plasmablastic lymphoma is composed of a monomorphic and cohesive pattern of plasmablasts with basophilic cytoplasm. Phenotypically, AIDS-related plasmablastic lymphoma fails to express the most common B-cell-associated surface antigens, whereas it consistently expresses high levels of plasma cell-associated markers, including VS38c and CD138/syndecan-1. For the purpose of differential diagnosis, the morphological and immunophenotypic peculiarities of AIDS- related plasmablastic lymphoma clearly distinguish these lymphomas from other categories of AIDS-related non-Hodgkin's lymphomas, as well as from undifferentiated large cell carcinomas.

Lingua originaleInglese
pagine (da-a)95-99
Numero di pagine5
RivistaAnnals of Otology, Rhinology and Laryngology
Volume108
Numero di pubblicazione1
DOI
Stato di pubblicazionePubblicato - 1999
Pubblicato esternamente

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