Aggregation in amphiphilic macrocycle-substituted Gd(3+) DOTA-type chelates is affected by the regiochemistry of substitution

Benjamin C Webber; Claudio CASSINO; Mauro BOTTA; Mark Woods

doi:10.1021/ic5028724

Aggregation in amphiphilic macrocycle-substituted Gd(3+) DOTA-type chelates is affected by the regiochemistry of substitution

Benjamin C Webber, Claudio CASSINO, Mauro BOTTA, Mark Woods

Dipartimento di Scienze e Innovazione Tecnologica

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

Gd(3+) chelates of macrocyclic bifunctional chelators (BFCs) can differentiate into two regioisomers: corner and side. These isomers afford different orientations of chelate relative to conjugate. These differences alter the self-assembly, tumbling, and effectiveness as magnetic resonance imaging contrast agents of the two biphenyl conjugate isomers.

Lingua originale	Inglese
pagine (da-a)	2085-2087
Numero di pagine	3
Rivista	Inorganic Chemistry
Volume	54
Numero di pubblicazione	5
DOI	https://doi.org/10.1021/ic5028724
Stato di pubblicazione	Pubblicato - 2015

Keywords

Chelating Agents
Contrast Media
Heterocyclic Compounds
Macrocyclic Compounds
Magnetic Resonance Imaging
Molecular Conformation
Organometallic Compounds
Stereoisomerism
Surface-Active Agents

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10.1021/ic5028724

http://hdl.handle.net/11579/70093

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title = "Aggregation in amphiphilic macrocycle-substituted Gd(3+) DOTA-type chelates is affected by the regiochemistry of substitution",

abstract = "Gd(3+) chelates of macrocyclic bifunctional chelators (BFCs) can differentiate into two regioisomers: corner and side. These isomers afford different orientations of chelate relative to conjugate. These differences alter the self-assembly, tumbling, and effectiveness as magnetic resonance imaging contrast agents of the two biphenyl conjugate isomers.",

keywords = "Chelating Agents, Contrast Media, Heterocyclic Compounds, Macrocyclic Compounds, Magnetic Resonance Imaging, Molecular Conformation, Organometallic Compounds, Stereoisomerism, Surface-Active Agents, Chelating Agents, Contrast Media, Heterocyclic Compounds, Macrocyclic Compounds, Magnetic Resonance Imaging, Molecular Conformation, Organometallic Compounds, Stereoisomerism, Surface-Active Agents",

author = "Webber, {Benjamin C} and Claudio CASSINO and Mauro BOTTA and Mark Woods",

note = "Publisher Copyright: {\textcopyright} 2015 American Chemical Society.",

year = "2015",

doi = "10.1021/ic5028724",

language = "English",

volume = "54",

pages = "2085--2087",

journal = "Inorganic Chemistry",

issn = "0020-1669",

publisher = "American Chemical Society",

number = "5",

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TY - JOUR

T1 - Aggregation in amphiphilic macrocycle-substituted Gd(3+) DOTA-type chelates is affected by the regiochemistry of substitution

AU - Webber, Benjamin C

AU - CASSINO, Claudio

AU - BOTTA, Mauro

AU - Woods, Mark

PY - 2015

Y1 - 2015

N2 - Gd(3+) chelates of macrocyclic bifunctional chelators (BFCs) can differentiate into two regioisomers: corner and side. These isomers afford different orientations of chelate relative to conjugate. These differences alter the self-assembly, tumbling, and effectiveness as magnetic resonance imaging contrast agents of the two biphenyl conjugate isomers.

AB - Gd(3+) chelates of macrocyclic bifunctional chelators (BFCs) can differentiate into two regioisomers: corner and side. These isomers afford different orientations of chelate relative to conjugate. These differences alter the self-assembly, tumbling, and effectiveness as magnetic resonance imaging contrast agents of the two biphenyl conjugate isomers.

KW - Chelating Agents

KW - Contrast Media

KW - Heterocyclic Compounds

KW - Macrocyclic Compounds

KW - Magnetic Resonance Imaging

KW - Molecular Conformation

KW - Organometallic Compounds

KW - Stereoisomerism

KW - Surface-Active Agents

KW - Chelating Agents

KW - Contrast Media

KW - Heterocyclic Compounds

KW - Macrocyclic Compounds

KW - Magnetic Resonance Imaging

KW - Molecular Conformation

KW - Organometallic Compounds

KW - Stereoisomerism

KW - Surface-Active Agents

UR - https://iris.uniupo.it/handle/11579/70093

U2 - 10.1021/ic5028724

DO - 10.1021/ic5028724

M3 - Article

SN - 0020-1669

VL - 54

SP - 2085

EP - 2087

JO - Inorganic Chemistry

JF - Inorganic Chemistry

IS - 5

ER -

Aggregation in amphiphilic macrocycle-substituted Gd(3+) DOTA-type chelates is affected by the regiochemistry of substitution

Abstract

Keywords

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