TY - GEN
T1 - Agent based modeling of relapsing multiple sclerosis
T2 - 2018 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2018
AU - Pappalardo, Francesco
AU - Russo, Giulia
AU - Pennisi, Marzio
AU - Sgroi, Giuseppe
AU - Alessandro, Giuseppe
AU - Palumbo, Parasiliti
AU - Motta, Santo
AU - Maimone, Davide
AU - Chiacchio, Ferdinando
N1 - Publisher Copyright:
© 2018 IEEE.
PY - 2019/1/21
Y1 - 2019/1/21
N2 - In this work, we present the application of a computational modeling infrastructure named UISS (Universal Immune System Simulator) able to simulate the main features and dynamics of the immune system activities. We provide an extended version of UISS to simulate all the underlying MS pathogenesis and its interaction with the host immune system. We simulated MS patients with different relapsing-remitting courses. Even though the model can be further personalized employing immunological parameters and genetic information, based on the available data, we obtained simulation scenarios for each patient who matched the real clinical and MRI history. UISS may have the potential to assist MS specialists in predicting the course of the disease and the response to treatment.
AB - In this work, we present the application of a computational modeling infrastructure named UISS (Universal Immune System Simulator) able to simulate the main features and dynamics of the immune system activities. We provide an extended version of UISS to simulate all the underlying MS pathogenesis and its interaction with the host immune system. We simulated MS patients with different relapsing-remitting courses. Even though the model can be further personalized employing immunological parameters and genetic information, based on the available data, we obtained simulation scenarios for each patient who matched the real clinical and MRI history. UISS may have the potential to assist MS specialists in predicting the course of the disease and the response to treatment.
KW - artificial immune system
KW - immune modeling
KW - multiple sclerosis
KW - personalized therapy
UR - http://www.scopus.com/inward/record.url?scp=85062496780&partnerID=8YFLogxK
U2 - 10.1109/BIBM.2018.8621109
DO - 10.1109/BIBM.2018.8621109
M3 - Conference contribution
AN - SCOPUS:85062496780
T3 - Proceedings - 2018 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2018
SP - 1380
EP - 1385
BT - Proceedings - 2018 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2018
A2 - Schmidt, Harald
A2 - Griol, David
A2 - Wang, Haiying
A2 - Baumbach, Jan
A2 - Zheng, Huiru
A2 - Callejas, Zoraida
A2 - Hu, Xiaohua
A2 - Dickerson, Julie
A2 - Zhang, Le
PB - Institute of Electrical and Electronics Engineers Inc.
Y2 - 3 December 2018 through 6 December 2018
ER -