Advances in the Universal NMR Database approach. 2′-Substituted taxanes as probes for an improved protocol of diastereomeric differentiation

Paolo Dambruoso, Carla Bassarello, Giuseppe Bifulco, Giovanni Appendino, Arturo Battaglia, Gabriele Fontana, Luigi Gomez-Paloma

Risultato della ricerca: Contributo su rivistaArticolo in rivistapeer review

Abstract

(Graph Presented) The configuration of the α-substituted α-hydroxy-β-aminoester moiety in a series of 2′-substituted taxanes was analyzed according to the recently proposed Universal NMR Database (UDB) approach. A critical analysis of the results showed that modifications regarding chemical shift adjustment (so as to render the shifts virtually connectivity independent) were necessary to get consistent stereoassignments in this set of compounds. On this basis, a modified UDB-based strategy, especially tailored to the configurational assignment of densely substituted diastereomeric fragments, is proposed.

Lingua originaleInglese
pagine (da-a)983-986
Numero di pagine4
RivistaOrganic Letters
Volume7
Numero di pubblicazione6
DOI
Stato di pubblicazionePubblicato - 17 mar 2005
Pubblicato esternamente

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