Advanced cell-based modeling of the royal disease: characterization of the mutated F9 mRNA

Keyphrases

• 19th Century 20%
• 20th Century 20%
• Aberrant Splicing 20%
• Abnormal Splicing 20%
• Bona Fide 20%
• Cell-based 100%
• Cellular Mechanisms 20%
• Cellular Models 20%
• Clinical Variability 20%
• Disease Characterization 100%
• F9 Gene 20%
• Fibroblasts 20%
• Frameshift 20%
• Genetic Variability 20%
• Hemophilia B 60%
• Hemophilia Patients 20%
• Hepatocyte-like Cells 80%
• Induced Pluripotent Stem Cell-derived Hepatocytes 20%
• Induced Pluripotent Stem Cells (iPSCs) 60%
• Intronic mutation 20%
• Mechanistic Studies 20%
• MRNA Analysis 20%
• MRNA Level 100%
• Next-generation Sequencing 20%
• Nonsense-mediated Decay 40%
• Nucleotide Substitution 20%
• Premature Termination Codon 40%
• Queen Victoria 20%
• Rare mutation 20%
• Royal Disease 100%
• Royal Family 20%
• Skin Biopsy 20%
• Splicing mutation 20%

Biochemistry, Genetics and Molecular Biology

• Codon 40%
• Fibroblast 20%
• Genetic Divergence 20%
• Haemophilia B 60%
• Hepatocyte 80%
• Induced Pluripotent Stem Cell 80%
• Lifespan 20%
• Messenger RNA 100%
• Next Generation Sequencing 20%
• Nonsense-Mediated Decay 40%
• RNA 60%
• Wild Type 20%