TY - JOUR
T1 - Adjunctive effect of autologus platelet-rich fibrin to barrier membrane in the treatment of periodontal intrabony defects
AU - Panda, Saurav
AU - Sankari, Malaiappan
AU - Satpathy, Anurag
AU - Jayakumar, Doraiswamy
AU - Mozzati, Marco
AU - Mortellaro, Carmen
AU - Gallesio, Giorgia
AU - Taschieri, Silvio
AU - Del Fabbro, Massimo
N1 - Publisher Copyright:
Copyright © 2016 by Mutaz B. Habal, MD.
PY - 2016
Y1 - 2016
N2 - Background and Aim: Autologous platelet-rich fibrin (PRF) and barrier membranes in the treatment of intrabony defects in chronic periodontitis patients have shown significant clinical benefits. This study evaluates the additive effect of autologous PRF in combination with a barrier membrane versus the use of barrier membrane alone for the treatment of intrabony defects in chronic periodontitis patients. Methods: Arandomized split-mouth designwas used. Sixteen patients with 32 paired intrabony defects were included. In each patient 1 defect was treated using a resorbable collagen membrane along with PRF (test group) and the other defect by guided tissue regeneration alone (control group). The following clinical parameters were measured at baseline and after 9 months: plaque index, modified sulcus bleeding index, probing pocket depth, clinical attachment level, and gingival marginal level. The radiographic defect depth was also assessed at baseline and after 9 months. Results: Test group showed a statistically significant improvement for probing depth (P=0.002), clinical attachment level (P=0.001), and radiographic defect depth (P<0.001) after 9 months as compared with the control sites. Radiographic defect depth reduction was 58.19±13.24% in the test group as compared with 24.86±9.94% reduction in the control group. Conclusions: The adjunctive use of PRF in combination with barrier membrane is more effective in the treatment of intrabony defects in chronic periodontitis as compared with barrier membrane alone.
AB - Background and Aim: Autologous platelet-rich fibrin (PRF) and barrier membranes in the treatment of intrabony defects in chronic periodontitis patients have shown significant clinical benefits. This study evaluates the additive effect of autologous PRF in combination with a barrier membrane versus the use of barrier membrane alone for the treatment of intrabony defects in chronic periodontitis patients. Methods: Arandomized split-mouth designwas used. Sixteen patients with 32 paired intrabony defects were included. In each patient 1 defect was treated using a resorbable collagen membrane along with PRF (test group) and the other defect by guided tissue regeneration alone (control group). The following clinical parameters were measured at baseline and after 9 months: plaque index, modified sulcus bleeding index, probing pocket depth, clinical attachment level, and gingival marginal level. The radiographic defect depth was also assessed at baseline and after 9 months. Results: Test group showed a statistically significant improvement for probing depth (P=0.002), clinical attachment level (P=0.001), and radiographic defect depth (P<0.001) after 9 months as compared with the control sites. Radiographic defect depth reduction was 58.19±13.24% in the test group as compared with 24.86±9.94% reduction in the control group. Conclusions: The adjunctive use of PRF in combination with barrier membrane is more effective in the treatment of intrabony defects in chronic periodontitis as compared with barrier membrane alone.
KW - Barrier membrane
KW - Guided tissue regeneration
KW - Intrabony defects
KW - Periodontal regeneration
KW - Platelet-rich fibrin
KW - Randomized clinical trial
UR - http://www.scopus.com/inward/record.url?scp=84962477102&partnerID=8YFLogxK
U2 - 10.1097/SCS.0000000000002524
DO - 10.1097/SCS.0000000000002524
M3 - Article
SN - 1049-2275
VL - 27
SP - 691
EP - 696
JO - Journal of Craniofacial Surgery
JF - Journal of Craniofacial Surgery
IS - 3
ER -