TY - JOUR
T1 - Adipose derived stem cells versus micro-fragmented adipose tissue in cartilage tissue regeneration and repair
AU - Beatrice, Castiglioni
AU - Massimiliano, Leigheb
AU - BOSETTI, Michela
PY - 2023
Y1 - 2023
N2 - In recent years, the aim of regenerative medicine strategies is to develop therapeutic conservative approaches for the treatment of musculoskeletal injuries. among these, the use of adult mesenchymal stem cells (MScs) has represented the main instrument for the treatment of cartilage lesions in osteoarthritis, considered as chronic degenerative diseases with little chance of therapy. MScs have shown promising cartilage repair from in-vitro, in-vivo, and clinical studies thanks to their self-renewing potential and multilineage differentiation capability, better if included in a 3d autologous scaffold. adipose tissue could be considered an optimal source of stem cells called adipose derived stem cells (adScs) being a tissue easily available in large amounts and obtained through minus invasive procedures than others, but it has not to be underestimated the limits before implantation: in-vitro step variability, cell expansion, destruction of the original tissue with the loss of cells natural niche and of their long-term efficacy. To overcome this issue, lipoaspirate clusters, also called micro-fragmented adipose tissue (MFat), provide stem cells in an intact stromal vascular niche with a high regenerative capacity. this review provides a comparative view of stem cells and lipoaspirate in terms of their sources, structure, properties and regenerative capacity. Moreover, are reviewed the most representative scientific papers showing in-vitro, in-vivo, and clinical results comparing adScs versus MFAT in the treatment of degenerative and inflammatory cartilage disease.
AB - In recent years, the aim of regenerative medicine strategies is to develop therapeutic conservative approaches for the treatment of musculoskeletal injuries. among these, the use of adult mesenchymal stem cells (MScs) has represented the main instrument for the treatment of cartilage lesions in osteoarthritis, considered as chronic degenerative diseases with little chance of therapy. MScs have shown promising cartilage repair from in-vitro, in-vivo, and clinical studies thanks to their self-renewing potential and multilineage differentiation capability, better if included in a 3d autologous scaffold. adipose tissue could be considered an optimal source of stem cells called adipose derived stem cells (adScs) being a tissue easily available in large amounts and obtained through minus invasive procedures than others, but it has not to be underestimated the limits before implantation: in-vitro step variability, cell expansion, destruction of the original tissue with the loss of cells natural niche and of their long-term efficacy. To overcome this issue, lipoaspirate clusters, also called micro-fragmented adipose tissue (MFat), provide stem cells in an intact stromal vascular niche with a high regenerative capacity. this review provides a comparative view of stem cells and lipoaspirate in terms of their sources, structure, properties and regenerative capacity. Moreover, are reviewed the most representative scientific papers showing in-vitro, in-vivo, and clinical results comparing adScs versus MFAT in the treatment of degenerative and inflammatory cartilage disease.
KW - Guided tissue regeneration
KW - Stem cells
KW - adipose tissue
KW - cartilage
KW - Guided tissue regeneration
KW - Stem cells
KW - adipose tissue
KW - cartilage
UR - https://iris.uniupo.it/handle/11579/195142
U2 - 10.23736/S0393-3660.23.05381-0
DO - 10.23736/S0393-3660.23.05381-0
M3 - Article
SN - 1827-1812
VL - 182
SP - 995
EP - 1002
JO - GAZZETTA MEDICA ITALIANA. ARCHIVIO PER LE SCIENZE MEDICHE
JF - GAZZETTA MEDICA ITALIANA. ARCHIVIO PER LE SCIENZE MEDICHE
IS - 12
ER -