Adherence to the mediterranean diet and lymphoma risk in the european prospective investigation into cancer and nutrition

M. Solans; Y. Benavente; M. Saez; A. Agudo; S. Naudin; F. S. Hosnijeh; H. Noh; H. Freisling; P. Ferrari; C. Besson; Y. Mahamat-Saleh; Boutron-Ruault M. -C.; T. Kuhn; R. Kaaks; H. Boeing; C. Lasheras; M. Rodriguez-Barranco; P. Amiano; J. M. Huerta; A. Barricarte; J. A. Schmidt; P. Vineis; E. Riboli; A. Trichopoulou; C. Bamia; E. Peppa; G. Masala; C. Agnoli; R. Tumino; Carlotta SACERDOTE; S. Panico; G. Skeie; E. Weiderpass; M. Jerkeman; U. Ericson; F. Spath; L. M. Nilsson; C. C. Dahm; K. Overvad; A. K. Bolvig; A. Tjonneland; S. de Sanjose; G. Buckland; R. Vermeulen; A. Nieters; D. Casabonne

doi:10.1002/ijc.32091

Adherence to the mediterranean diet and lymphoma risk in the european prospective investigation into cancer and nutrition

M. Solans, Y. Benavente, M. Saez, A. Agudo, S. Naudin, F. S. Hosnijeh, H. Noh, H. Freisling, P. Ferrari, C. Besson, Y. Mahamat-Saleh, Boutron-Ruault M. -C., T. Kuhn, R. Kaaks, H. Boeing, C. Lasheras, M. Rodriguez-Barranco, P. Amiano, J. M. Huerta, A. BarricarteJ. A. Schmidt, P. Vineis, E. Riboli, A. Trichopoulou, C. Bamia, E. Peppa, G. Masala, C. Agnoli, R. Tumino, Carlotta SACERDOTE, S. Panico, G. Skeie, E. Weiderpass, M. Jerkeman, U. Ericson, F. Spath, L. M. Nilsson, C. C. Dahm, K. Overvad, A. K. Bolvig, A. Tjonneland, S. de Sanjose, G. Buckland, R. Vermeulen, A. Nieters, D. Casabonne

Dipartimento di Scienze della Salute

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

There is a growing evidence of the protective role of the Mediterranean diet (MD) on cancer. However, no prospective study has yet investigated its influence on lymphoma. We evaluated the association between adherence to the MD and risk of lymphoma and its subtypes in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. The analysis included 476,160 participants, recruited from 10 European countries between 1991 and 2001. Adherence to the MD was estimated through the adapted relative MD (arMED) score excluding alcohol. Cox proportional hazards regression models were used while adjusting for potential confounders. During an average follow-up of 13.9 years, 3,136 lymphomas (135 Hodgkin lymphoma [HL], 2,606 non-HL and 395 lymphoma not otherwise specified) were identified. Overall, a 1-unit increase in the arMED score was associated with a 2% lower risk of lymphoma (95% CI: 0.97; 1.00, p-trend = 0.03) while a statistically nonsignificant inverse association between a high versus low arMED score and risk of lymphoma was observed (hazard ratio [HR]: 0.91 [95% CI 0.80; 1.03], p-trend = 0.12). Analyses by lymphoma subtype did not reveal any statistically significant associations. Albeit with small numbers of cases (N = 135), a suggestive inverse association was found for HL (HR 1-unit increase = 0.93 [95% CI: 0.86; 1.01], p-trend = 0.07). However, the study may have lacked statistical power to detect small effect sizes for lymphoma subtype. Our findings suggest that an increasing arMED score was inversely related to the risk of overall lymphoma in EPIC but not by subtypes. Further large prospective studies are warranted to confirm these findings.

Lingua originale	Inglese
pagine (da-a)	122-131
Numero di pagine	10
Rivista	International Journal of Cancer
Volume	145
Numero di pubblicazione	1
DOI	https://doi.org/10.1002/ijc.32091
Stato di pubblicazione	Pubblicato - 2019

Keywords

Europe
lymphoma
Mediterranean diet
prospective studies
risk

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10.1002/ijc.32091

https://hdl.handle.net/11579/200128

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Solans, M., Benavente, Y., Saez, M., Agudo, A., Naudin, S., Hosnijeh, F. S., Noh, H., Freisling, H., Ferrari, P., Besson, C., Mahamat-Saleh, Y., -C., B.-R. M., Kuhn, T., Kaaks, R., Boeing, H., Lasheras, C., Rodriguez-Barranco, M., Amiano, P., Huerta, J. M., ... Casabonne, D. (2019). Adherence to the mediterranean diet and lymphoma risk in the european prospective investigation into cancer and nutrition. International Journal of Cancer, 145(1), 122-131. https://doi.org/10.1002/ijc.32091

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title = "Adherence to the mediterranean diet and lymphoma risk in the european prospective investigation into cancer and nutrition",

abstract = "There is a growing evidence of the protective role of the Mediterranean diet (MD) on cancer. However, no prospective study has yet investigated its influence on lymphoma. We evaluated the association between adherence to the MD and risk of lymphoma and its subtypes in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. The analysis included 476,160 participants, recruited from 10 European countries between 1991 and 2001. Adherence to the MD was estimated through the adapted relative MD (arMED) score excluding alcohol. Cox proportional hazards regression models were used while adjusting for potential confounders. During an average follow-up of 13.9 years, 3,136 lymphomas (135 Hodgkin lymphoma [HL], 2,606 non-HL and 395 lymphoma not otherwise specified) were identified. Overall, a 1-unit increase in the arMED score was associated with a 2% lower risk of lymphoma (95% CI: 0.97; 1.00, p-trend = 0.03) while a statistically nonsignificant inverse association between a high versus low arMED score and risk of lymphoma was observed (hazard ratio [HR]: 0.91 [95% CI 0.80; 1.03], p-trend = 0.12). Analyses by lymphoma subtype did not reveal any statistically significant associations. Albeit with small numbers of cases (N = 135), a suggestive inverse association was found for HL (HR 1-unit increase = 0.93 [95% CI: 0.86; 1.01], p-trend = 0.07). However, the study may have lacked statistical power to detect small effect sizes for lymphoma subtype. Our findings suggest that an increasing arMED score was inversely related to the risk of overall lymphoma in EPIC but not by subtypes. Further large prospective studies are warranted to confirm these findings.",

keywords = "Europe, lymphoma, Mediterranean diet, prospective studies, risk, Europe, lymphoma, Mediterranean diet, prospective studies, risk",

author = "M. Solans and Y. Benavente and M. Saez and A. Agudo and S. Naudin and Hosnijeh, {F. S.} and H. Noh and H. Freisling and P. Ferrari and C. Besson and Y. Mahamat-Saleh and -C., {Boutron-Ruault M.} and T. Kuhn and R. Kaaks and H. Boeing and C. Lasheras and M. Rodriguez-Barranco and P. Amiano and Huerta, {J. M.} and A. Barricarte and Schmidt, {J. A.} and P. Vineis and E. Riboli and A. Trichopoulou and C. Bamia and E. Peppa and G. Masala and C. Agnoli and R. Tumino and Carlotta SACERDOTE and S. Panico and G. Skeie and E. Weiderpass and M. Jerkeman and U. Ericson and F. Spath and Nilsson, {L. M.} and Dahm, {C. C.} and K. Overvad and Bolvig, {A. K.} and A. Tjonneland and {de Sanjose}, S. and G. Buckland and R. Vermeulen and A. Nieters and D. Casabonne",

year = "2019",

doi = "10.1002/ijc.32091",

language = "English",

volume = "145",

pages = "122--131",

journal = "International Journal of Cancer",

issn = "0020-7136",

publisher = "John Wiley and Sons Inc.",

number = "1",

}

Solans, M, Benavente, Y, Saez, M, Agudo, A, Naudin, S, Hosnijeh, FS, Noh, H, Freisling, H, Ferrari, P, Besson, C, Mahamat-Saleh, Y, -C., B-RM, Kuhn, T, Kaaks, R, Boeing, H, Lasheras, C, Rodriguez-Barranco, M, Amiano, P, Huerta, JM, Barricarte, A, Schmidt, JA, Vineis, P, Riboli, E, Trichopoulou, A, Bamia, C, Peppa, E, Masala, G, Agnoli, C, Tumino, R, SACERDOTE, C, Panico, S, Skeie, G, Weiderpass, E, Jerkeman, M, Ericson, U, Spath, F, Nilsson, LM, Dahm, CC, Overvad, K, Bolvig, AK, Tjonneland, A, de Sanjose, S, Buckland, G, Vermeulen, R, Nieters, A & Casabonne, D 2019, 'Adherence to the mediterranean diet and lymphoma risk in the european prospective investigation into cancer and nutrition', International Journal of Cancer, vol. 145, n. 1, pagg. 122-131. https://doi.org/10.1002/ijc.32091

TY - JOUR

T1 - Adherence to the mediterranean diet and lymphoma risk in the european prospective investigation into cancer and nutrition

AU - Solans, M.

AU - Benavente, Y.

AU - Saez, M.

AU - Agudo, A.

AU - Naudin, S.

AU - Hosnijeh, F. S.

AU - Noh, H.

AU - Freisling, H.

AU - Ferrari, P.

AU - Besson, C.

AU - Mahamat-Saleh, Y.

AU - -C., Boutron-Ruault M.

AU - Kuhn, T.

AU - Kaaks, R.

AU - Boeing, H.

AU - Lasheras, C.

AU - Rodriguez-Barranco, M.

AU - Amiano, P.

AU - Huerta, J. M.

AU - Barricarte, A.

AU - Schmidt, J. A.

AU - Vineis, P.

AU - Riboli, E.

AU - Trichopoulou, A.

AU - Bamia, C.

AU - Peppa, E.

AU - Masala, G.

AU - Agnoli, C.

AU - Tumino, R.

AU - SACERDOTE, Carlotta

AU - Panico, S.

AU - Skeie, G.

AU - Weiderpass, E.

AU - Jerkeman, M.

AU - Ericson, U.

AU - Spath, F.

AU - Nilsson, L. M.

AU - Dahm, C. C.

AU - Overvad, K.

AU - Bolvig, A. K.

AU - Tjonneland, A.

AU - de Sanjose, S.

AU - Buckland, G.

AU - Vermeulen, R.

AU - Nieters, A.

AU - Casabonne, D.

PY - 2019

Y1 - 2019

N2 - There is a growing evidence of the protective role of the Mediterranean diet (MD) on cancer. However, no prospective study has yet investigated its influence on lymphoma. We evaluated the association between adherence to the MD and risk of lymphoma and its subtypes in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. The analysis included 476,160 participants, recruited from 10 European countries between 1991 and 2001. Adherence to the MD was estimated through the adapted relative MD (arMED) score excluding alcohol. Cox proportional hazards regression models were used while adjusting for potential confounders. During an average follow-up of 13.9 years, 3,136 lymphomas (135 Hodgkin lymphoma [HL], 2,606 non-HL and 395 lymphoma not otherwise specified) were identified. Overall, a 1-unit increase in the arMED score was associated with a 2% lower risk of lymphoma (95% CI: 0.97; 1.00, p-trend = 0.03) while a statistically nonsignificant inverse association between a high versus low arMED score and risk of lymphoma was observed (hazard ratio [HR]: 0.91 [95% CI 0.80; 1.03], p-trend = 0.12). Analyses by lymphoma subtype did not reveal any statistically significant associations. Albeit with small numbers of cases (N = 135), a suggestive inverse association was found for HL (HR 1-unit increase = 0.93 [95% CI: 0.86; 1.01], p-trend = 0.07). However, the study may have lacked statistical power to detect small effect sizes for lymphoma subtype. Our findings suggest that an increasing arMED score was inversely related to the risk of overall lymphoma in EPIC but not by subtypes. Further large prospective studies are warranted to confirm these findings.

AB - There is a growing evidence of the protective role of the Mediterranean diet (MD) on cancer. However, no prospective study has yet investigated its influence on lymphoma. We evaluated the association between adherence to the MD and risk of lymphoma and its subtypes in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. The analysis included 476,160 participants, recruited from 10 European countries between 1991 and 2001. Adherence to the MD was estimated through the adapted relative MD (arMED) score excluding alcohol. Cox proportional hazards regression models were used while adjusting for potential confounders. During an average follow-up of 13.9 years, 3,136 lymphomas (135 Hodgkin lymphoma [HL], 2,606 non-HL and 395 lymphoma not otherwise specified) were identified. Overall, a 1-unit increase in the arMED score was associated with a 2% lower risk of lymphoma (95% CI: 0.97; 1.00, p-trend = 0.03) while a statistically nonsignificant inverse association between a high versus low arMED score and risk of lymphoma was observed (hazard ratio [HR]: 0.91 [95% CI 0.80; 1.03], p-trend = 0.12). Analyses by lymphoma subtype did not reveal any statistically significant associations. Albeit with small numbers of cases (N = 135), a suggestive inverse association was found for HL (HR 1-unit increase = 0.93 [95% CI: 0.86; 1.01], p-trend = 0.07). However, the study may have lacked statistical power to detect small effect sizes for lymphoma subtype. Our findings suggest that an increasing arMED score was inversely related to the risk of overall lymphoma in EPIC but not by subtypes. Further large prospective studies are warranted to confirm these findings.

KW - Europe

KW - lymphoma

KW - Mediterranean diet

KW - prospective studies

KW - risk

KW - Europe

KW - lymphoma

KW - Mediterranean diet

KW - prospective studies

KW - risk

UR - https://iris.uniupo.it/handle/11579/200128

U2 - 10.1002/ijc.32091

DO - 10.1002/ijc.32091

M3 - Article

SN - 0020-7136

VL - 145

SP - 122

EP - 131

JO - International Journal of Cancer

JF - International Journal of Cancer

IS - 1

ER -

Adherence to the mediterranean diet and lymphoma risk in the european prospective investigation into cancer and nutrition

Abstract

Keywords

OSS delle Nazioni Unite

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