Acyclic analogs of classical H2-antagonists: synthesis and activity of dialkylamioalkyl substituted ethers and oximes

Giovanni Sorba; Roberta Fruttero; Alberto Gasco; Marco Orsetti

doi:10.1016/0223-5234(87)90058-4

Acyclic analogs of classical H₂-antagonists: synthesis and activity of dialkylamioalkyl substituted ethers and oximes

Giovanni Sorba, Roberta Fruttero, Alberto Gasco, Marco Orsetti

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

A few dialkylaminoalkyl substituted ethers and oximes structurally related to classical H₂-antagonists have been synthesized and tested for their in vitro (guinea pig isolated atrium) H₂-antagonistic activities. Some of them are inactive others display activity. Structure-activity relationships are also discussed.

Lingua originale	Inglese
pagine (da-a)	255-259
Numero di pagine	5
Rivista	European Journal of Medicinal Chemistry
Volume	22
Numero di pubblicazione	3
DOI	https://doi.org/10.1016/0223-5234(87)90058-4
Stato di pubblicazione	Pubblicato - 1987
Pubblicato esternamente	Sì

Accesso al documento

10.1016/0223-5234(87)90058-4

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title = "Acyclic analogs of classical H2-antagonists: synthesis and activity of dialkylamioalkyl substituted ethers and oximes",

abstract = "A few dialkylaminoalkyl substituted ethers and oximes structurally related to classical H2-antagonists have been synthesized and tested for their in vitro (guinea pig isolated atrium) H2-antagonistic activities. Some of them are inactive others display activity. Structure-activity relationships are also discussed.",

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AU - Orsetti, Marco

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AB - A few dialkylaminoalkyl substituted ethers and oximes structurally related to classical H2-antagonists have been synthesized and tested for their in vitro (guinea pig isolated atrium) H2-antagonistic activities. Some of them are inactive others display activity. Structure-activity relationships are also discussed.

KW - H-antagonistic activity

KW - ether derivatives

KW - furazan derivatives

KW - oxime derivatives

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